Oligoarticular juvenile idiopathic arthritis (oligo JIA) is the most common form of chronic
inflammatory arthritis in children, yet the cause of this disease remains unknown. To …

Systemic juvenile idiopathic arthritis (sJIA) begins with fever, rash, and high-grade systemic
inflammation but commonly progresses to a persistent afebrile arthritis. The basis for this …

Multifactorial diseases, including autoimmune juvenile idiopathic arthritis (JIA), result from a
complex interplay between genetics and environment. Epigenetic mechanisms are believed …

Background The transcriptomes of peripheral blood cells in children with juvenile idiopathic
arthritis (JIA) have distinct transcriptional aberrations that suggest impairment of …

Background Juvenile idiopathic arthritis (JIA) is an umbrella term of inflammatory joint
diseases in children. Oligoarthritis is the most common form in the Western world …

In juvenile idiopathic arthritis (JIA) inflammatory T cells and their produced cytokines are
drug targets and play a role in disease pathogenesis. Despite their clinical importance, the …

Objectives Juvenile idiopathic arthritis (JIA) is the most common class of childhood
rheumatic diseases, with distinct disease subsets that may have diverging …

Background Fibroblast-like synoviocytes (FLS) play a crucial role in JIA pathogenesis;
however, the mechanisms by which they contribute to disease progression are not well …

Introduction Monocytes are key effector cells in inflammatory processes. We and others have
previously shown that synovial monocytes in childhood-onset arthritis are activated …

Polyarticular juvenile idiopathic arthritis (JIA) is among the most challenging of the JIA
subtypes to treat. Even with current biologic therapies, the disease remains difficult to control …