In mammals, sperm fertilization potential relies on efficient progression within the female
genital tract to reach and fertilize the oocyte. This fundamental property is supported by the …

Mammalian sperm cells must respond to cues originating from along the female
reproductive tract and from the layers of the egg in order to complete their fertilization …

Investigation of ion channel biology continues to be an ever-expanding field of research.
The ability of ion channels to regulate membrane potential and intracellular ionic milieu …

There is a global need for an ideal method of male contraception. However, the
development of male contraceptives has not been well successful. Research on sperm …

Sexually reproducing animals require an orchestrated communication between
spermatozoa and the egg to generate a new individual. Capacitation, a maturational …

Ion channels control the sperm ability to fertilize the egg by regulating sperm maturation in
the female reproductive tract and by triggering key sperm physiological responses required …

Ion channels regulate the membrane potential and intracellular ionic concentration and thus
serve a central role in various cellular processes. Several ion channels have been identified …

Ion channels are extraordinarily efficient machines that move ions in diversely controlled
manners, allowing cells to rapidly exchange information with the outside world and with …

Upon ejaculation, mammalian spermatozoa have to undergo a sequence of physiological
transformations within the female reproductive tract that will allow them to reach and fertilize …

BACKGROUND Intensive research on sperm ion channels has identified members of
several ion channel families in both mouse and human sperm. Gene knock-out studies have …