Nuclear receptors (NRs) are ligand-binding transcription factors that regulate gene networks
and physiological responses. Often oxidative stress precedes the onset of liver diseases …

Abstract Nuclear erythroid 2-related factor 2 (Nrf2) is a central regulator of antioxidative
response elements-mediated gene expression. It has a significant role in adaptive …

Nuclear receptors (NR) are ligand-modulated transcription factors that play diverse roles in
cell differentiation, development, proliferation, and metabolism and are associated with …

The overproduction of reactive oxygen species (ROS) and consequent oxidative stress
contribute to the pathogenesis of acute and chronic liver diseases. It is now acknowledged …

Reactive oxygen and nitrogen species (ROS/RNS) are formed in the liver as a consequence
of normal cellular processes (eg, mitochondrial respiration and xenobiotic metabolism) …

Nuclear factor erythroid 2-related factor-2 (Nrf2) antioxidant signaling is involved in liver
protection, but this generalization overlooks conflicting studies indicating that Nrf2 effects are …

Liver-enriched nuclear receptors (NRs) collectively function as metabolic and toxicological
“sensors” that mediate liver-specific gene-activation in mammals. NR-mediated gene …

Nuclear erythroid 2–related factor 2 (Nrf2) is an oxidative stress–mediated transcription
factor with a variety of downstream targets aimed at cytoprotection. Nrf2 has recently been …

Abstract NF-E2–related factor 2 (Nrf2) is an essential transcription factor that regulates an
array of detoxifying and antioxidant defense gene expression in the liver. It is activated in …

Liver diseases represent a critical health problem with 2 million deaths worldwide per year,
mainly due to cirrhosis and its complications. Oxidative stress plays an important role in the …