Lymph nodes are the most common sites of metastasis in cancer patients. Nodal disease
status provides great prognostic power, but how lymph node metastases should be treated …

Tumor-associated lymphatic vessels play an important role in tumor progression, mediating
lymphatic dissemination of malignant cells to tumor-draining lymph nodes and regulating …

Highlights•Tumours induce growth and remodelling of lymphatics which is linked with
metastasis.•Lymphatic vessels modulate antitumour immunity in tumours and draining lymph …

Cancer metastasis is the process by which primary cancer cells invade through the
lymphatic or blood vessels to distant sites. The molecular mechanisms by which cancer cells …

Lymph nodes (LNs) are important hubs for metastatic cell arrest and growth, immune
modulation, and secondary dissemination to distant sites through a series of mechanisms …

Cancer patients with lymph node (LN) metastases have a worse prognosis than those
without nodal disease. However, why LN metastases correlate with reduced patient survival …

Distant organ metastasis is the most important factor in determining patient survival in
cancer. This is thought to occur via the body's own systems for transporting fluid and cells …

Tumor lymphangiogenesis is accompanied by a higher incidence of sentinel lymph node
metastasis and shorter overall survival in several types of cancer. We asked whether tumor …

Physiologically, the lymphatic system regulates fluid volume in the interstitium and provides
a conduit for immune cells to travel to lymph nodes, but pathologically, the lymphatic system …

Highlights•Tumor lymphangiogenesis is associated with a poor prognosis in many cancer
types.•Lymphatic vessels provide a dissemination route for tumor cells.•Lymphatic vessels …