The receptors for IL-3, GM-CSF, and IL-5 share a common 5 subunit (5c), and mice have an
additional IL-3 5 subunit (5~). We have independently generated mice carrying null …

Gene targeting was used to create mice with a null mutation of the gene encoding the
common beta subunit (beta C) of the granulocyte-macrophage colony-stimulating factor (GM …

The eosinophil is a central effector cell in allergic asthma. Differentiation and function of
eosinophils are regulated by the CD4 Th2 cytokines IL-3, IL-5, and GM-CSF, which all signal …

The receptors for granulocyte-macrophage colony-stimulating factor (GM-CSF) and
interleukin-3 and-5 (IL-3, IL-5) share a common signaling subunit (beta c). However, in the …

The high-affinity receptors for human interleukin-3 (IL-3), GM-CSF, and IL-5 are composed of
alpha and beta subunits. The alpha subunits are primary ligand binding proteins specific for …

Interleukin-3 (IL-3), granulocyte-macrophage colony-stimulating factor (GM-CSF), and IL-5
are major hematopoietic cytokines produced by activated T cells and exhibit similar biologic …

The human interleukin‐3 receptor (IL‐3R) is composed of an IL‐3 specific alpha subunit (IL‐
3R alpha) and a common beta subunit (beta c) that is shared by IL‐3, granulocyte …

Alveolar macrophages are poor APCs that only minimally express B7 costimulatory
molecules. Because our previous data suggest that bronchial epithelial cells constitutively …

In this report a method for the affinity purification and radiolabeling of recombinant mouse
interleukin (IL)-4 is described. It is shown on the basis of several criteria that IL-4 retains full …

KC, the product of an immediate early gene induced in mouse fibroblasts by platelet-derived
growth factor, was synthesized as a recombinant protein in Escherichia coli and binds with …