[HTML][HTML] Emerging concepts of miRNA therapeutics: from cells to clinic

C Diener, A Keller, E Meese - Trends in Genetics, 2022 - cell.com
MicroRNAs (miRNAs) are very powerful genetic regulators, as evidenced by the fact that a
single miRNA can direct entire cellular pathways via interacting with a broad spectrum of …

[HTML][HTML] miRNA-based therapeutic strategies

M Ishida, FM Selaru - Current Pathobiology Reports, 2013 - Springer
Micro-RNAs (miRNAs) are short, non-coding RNA species, thought to act primarily through
downregulation of target mRNA species with subsequent decrease in encoded proteins …

The road toward microRNA therapeutics

AG Seto - The international journal of biochemistry & cell biology, 2010 - Elsevier
Within the last 15 years, microRNAs (miRNAs) have emerged as powerful regulators of gene
expression. Highly conserved, these small RNAs appear to regulate nearly every aspect of …

Molecular therapy in the microRNA era

T Wurdinger, FF Costa - The pharmacogenomics journal, 2007 - nature.com
MicroRNAs (miRNAs) consist of a growing class of non-coding RNAs (ncRNAs) that
negatively regulate the expression of genes involved in development, differentiation …

Innovative approaches in transforming microRNAs into therapeutic tools

AFA Samad, MF Kamaroddin - Wiley Interdisciplinary Reviews …, 2023 - Wiley Online Library
MicroRNA (miRNA) is regarded as a prominent genetic regulator, as it can fine‐tune an
entire biological pathway by targeting multiple target genes. This characteristic makes …

[HTML][HTML] MicroRNAs in disease and potential therapeutic applications

HS Soifer, JJ Rossi, P Sætrom - Molecular therapy, 2007 - cell.com
MicroRNAs (miRNAs) are 21–24 nucleotide (nt) duplex RNAs that are created from
precursor transcripts by subsequent processing steps mediated by members of the RNAseIII …

[HTML][HTML] The challenges and opportunities in the development of MicroRNA therapeutics: a multidisciplinary viewpoint

MY Momin, RR Gaddam, M Kravitz, A Gupta, A Vikram - Cells, 2021 - mdpi.com
microRNAs (miRs) are emerging as attractive therapeutic targets because of their small size,
specific targetability, and critical role in disease pathogenesis. However,< 20 miR targeting …

The therapeutic potential of microRNAs: disease modulators and drug targets

AM McDermott, HM Heneghan, N Miller… - Pharmaceutical …, 2011 - Springer
MiRNAs are a class of small, naturally occurring RNA molecules that play critical roles in
modulating numerous biological pathways by regulating gene expression. The knowledge …

[HTML][HTML] MicroRNA therapeutics: discovering novel targets and developing specific therapy

AF Christopher, RP Kaur, G Kaur, A Kaur… - … in clinical research, 2016 - journals.lww.com
MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression
in diverse biological process. They act as intracellular mediators that are necessary for …

microRNAs as cancer therapeutics: A step closer to clinical application

TC Ivkovic, G Voss, H Cornella, Y Ceder - Cancer letters, 2017 - Elsevier
During the last decades, basic and translational research has enabled great improvements
in the clinical management of cancer. However, scarcity of complete remission and many …