Feedback is both a pillar of control theory and a pervasive principle of nature. For this
reason, control-theoretic methods are powerful to analyse the dynamic behaviour of …

A major issue in systems biology, which is well studied in control theory, is the analysis of
feedback circuits in a dynamical system. These circuits endow biological systems with …

Systems biology is an interdisciplinary field that aims at understanding complex interactions
in cells. Here we demonstrate that linear control theory can provide valuable insight and …

The fields of molecular biology and cell biology are being flooded with complex genomic
and proteomic datasets of large dimensions. We now recognize that each molecule in the …

Despite their complexity, biological systems are able to endure huge parameter fluctuations
and survive in the most diverse environmental conditions. Mathematical tools from graph …

Molecular Systems Biology and Control: A Qualitative-Quantitative Approach Page 1 Molecular
Systems Biology and Control: A Qualitative-Quantitative Approach Eduardo D. Sontag ∗ …

Feedback circuits are network motifs that are important for the proper regulation of various
cellular processes. Moreover, feedback is related to complex dynamic behavior such as …

Biological systems compute spatial and temporal gradients with a variety of mechanisms,
some of which have been shown to include integral feedback. In traditional engineering …

The emerging field at the intersection of quantitative biology, network modeling, and control
theory has enjoyed significant progress in recent years. This Special Issue brings together a …

Time-scale separation is a powerful property that can be used to simplify control systems
design. In this work, we consider the problem of designing biomolecular feedback …