The goal of cancer research is to identify characteristics of cancer cells that allow them to be
selectively eliminated without harming the host. One such characteristic is autophagy …

High-throughput screening identified 5 chemical analogs (termed the WX8-family) that
disrupted 3 events in lysosome homeostasis:(1) lysosome fission via tubulation without …

In nutrient-poor conditions, autophagy buffers metabolic stress and counteracts the effects of
chemotherapy and radiation on cancer cells, which depend on autophagy for survival …

Autophagy is a catabolic process involving lysosomal turnover of proteins and organelles for
maintenance of cellular homeostasis and mitigation of metabolic stress. Autophagy defects …

Anticancer therapies reportedly promote pro-survival autophagy in cancer cells that confers
drug resistance, rationalizing the concept to combine autophagy inhibitors to increase their …

Inhibitors specifically targeting the 1‐phosphatidylinositol 3‐phosphate 5‐kinase (PIKFYVE)
disrupt lysosome homeostasis, thereby selectively terminating autophagy‐dependent …

The phosphoinositide 3-kinase (PI3K) pathway plays a crucial role in cell proliferation and
survival and is frequently activated by genetic and epigenetic alterations in human cancer …

Autophagy, a degradation mechanism conserved among eukaryotes, plays an important
role in cellular homeostasis by maintaining nutrients and energy balance. It is not surprising …

Autophagy is a highly conserved lysosomal degradation process which can recycle
unnecessary or dysfunctional cell organelles and proteins, thereby playing a crucial …

Autophagy is an intracellular degradation and recycling system that aids in maintaining the
cellular metabolism and homeostasis. Various cellular stresses, including organelle …