[HTML][HTML] Borneol ester derivatives as entry inhibitors of a wide spectrum of SARS-CoV-2 viruses

OI Yarovaya, DN Shcherbakov, SS Borisevich… - Viruses, 2022 - mdpi.com
In the present work we studied the antiviral activity of the home library of monoterpenoid
derivatives using the pseudoviral systems of our development, which have glycoproteins of …

[HTML][HTML] Screening of natural products inhibitors of SARS-CoV-2 entry

P González-Maldonado, N Alvarenga… - Molecules, 2022 - mdpi.com
The COVID-19 pandemic has led to the search for new molecules with antiviral activity
against SARS-CoV-2. The entry of the virus into the cell is one of the main targets for …

[HTML][HTML] Identification of bis-benzylisoquinoline alkaloids as SARS-CoV-2 entry inhibitors from a library of natural products

CL He, LY Huang, K Wang, CJ Gu, J Hu… - Signal transduction and …, 2021 - nature.com
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) is a major public health issue. The spike (S) protein mutation …

[HTML][HTML] Simulation of Molecular Dynamics of SARS-CoV-2 S-Protein in the Presence of Multiple Arbidol Molecules: Interactions and Binding Mode Insights

SS Borisevich, EM Khamitov, MA Gureev, OI Yarovaya… - Viruses, 2022 - mdpi.com
In this work, we evaluated the antiviral activity of Arbidol (Umifenovir) against SARS-CoV-2
using a pseudoviral system with the glycoprotein S of the SARS-CoV-2 virus on its surface …

[HTML][HTML] An Integrated In Silico and In Vitro Approach for the Identification of Natural Products Active against SARS-CoV-2

R Pennisi, D Gentile, A Rescifina, E Napoli, P Trischitta… - Biomolecules, 2023 - mdpi.com
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), has provoked a global health crisis due to the absence of a …

Identification of potential inhibitors against SARS-CoV-2 by targeting proteins responsible for envelope formation and virion assembly using docking based virtual …

D Bhowmik, R Nandi, R Jagadeesan, N Kumar… - Infection, Genetics and …, 2020 - Elsevier
WHO has declared the outbreak of COVID-19 as a public health emergency of international
concern. The ever-growing new cases have called for an urgent emergency for specific anti …

SARS-CoV-2 host cell entry: an in silico investigation of potential inhibitory roles of terpenoids

GA Gyebi, OM Ogunyemi, IM Ibrahim… - Journal of Genetic …, 2021 - Elsevier
Background Targeting viral cell entry proteins is an emerging therapeutic strategy for
inhibiting the first stage of SARS-CoV-2 infection. In this study, 106 bioactive terpenoids from …

An updated review on betacoronavirus viral entry inhibitors: learning from past discoveries to advance COVID-19 drug discovery

DA Sabbah, R Hajjo, SK Bardaweel… - Current Topics in …, 2021 - ingentaconnect.com
Even after one year of its first outbreak reported in China, the coronavirus disease 2019
(COVID-19) pandemic is still sweeping the World, causing serious infections and claiming …

In silico identification of strong binders of the SARS-CoV-2 receptor-binding domain

N Behloul, S Baha, Y Guo, Z Yang, R Shi… - European Journal of …, 2021 - Elsevier
The world is currently witnessing the spread of the deadly severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) that causes the coronavirus disease 2019 (COVID …

[HTML][HTML] Inhibition of SARS-CoV-2 entry into host cells using small molecules

K Al Adem, A Shanti, C Stefanini, S Lee - Pharmaceuticals, 2020 - mdpi.com
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), a virus belonging to the
Coronavirus family, is now known to cause Coronavirus Disease (Covid-19) which was first …