2019 Coronavirus Disease (COVID-19) is a global pandemic caused by severe acute
respiratory syndrome coronavirus-2 (SARS-CoV-2). A “cytokine storm”, ie, elevated levels of …

Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), exhibits a wide spectrum of clinical presentations …

NLRP3 inflammasome is a critical immune component that plays a crucial role in mounting
innate immune responses. The deleterious effects of inflammasome activation have been …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a member of the genus
Betacoronavirus within the family Coronaviridae. It is an enveloped single-stranded positive …

NLRP3 (NOD-, LRR-and pyrin domain-containing protein 3) inflammasome has recently
become an intriguing target of several chronic and viral diseases. Here, we argue that …

Severe SARS-CoV-2 infection causes systemic inflammation, cytokine storm, and
hypercytokinemia due to activation of the release of pro-inflammatory cytokines that have …

Novel coronaviruses (nCoVs) encode ion-channel proteins called viroporins such as protein
E, open reading frame 3a (ORF3a) and ORF8a. These viroporins, via mechanisms such as …

Summary Background The Coronavirus Disease 2019 (COVID-19) pandemic has been a
great threat to global public health since 2020. Although the advance on vaccine …

Following entry and replication of Severe Acute Respiratory Syndrome-coronavirus-2 (SARS-
CoV-2) into ACE2 expressing cells, the infected cells undergo lysis releasing more virus but …

COVID‐19, the illness caused by SARS‐CoV‐2, has a wide‐ranging clinical spectrum that,
in the worst‐case scenario, involves a rapid progression to severe acute respiratory …