In vivo delivery of miRNAs for cancer therapy: challenges and strategies

Y Chen, DY Gao, L Huang - Advanced drug delivery reviews, 2015 - Elsevier
Abstract MicroRNAs (miRNAs), small non-coding RNAs, can regulate post-transcriptional
gene expressions and silence a broad set of target genes. miRNAs, aberrantly expressed in …

miRacle of microRNA-driven cancer nanotherapeutics

G Kara, B Arun, GA Calin, B Ozpolat - Cancers, 2022 - mdpi.com
Simple Summary The discovery of microRNAs has revolutionized the world of science and
opened up new opportunities in cancer treatment. miRNA dysregulation plays a crucial role …

MicroRNA therapeutics in cancer: current advances and challenges

S Reda El Sayed, J Cristante, L Guyon, J Denis… - Cancers, 2021 - mdpi.com
Simple Summary Cancer is a complex disease associated with deregulation of numerous
genes. In addition, redundant cellular pathways limit efficiency of monotarget drugs in …

Recent progress in microRNA delivery for cancer therapy by non-viral synthetic vectors

H Wang, Y Jiang, H Peng, Y Chen, P Zhu… - Advanced drug delivery …, 2015 - Elsevier
MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression. Because
of significant changes in their expression in cancer, miRNAs are believed to be key factors in …

Delivering the promise of miRNA cancer therapeutics

DM Pereira, PM Rodrigues, PM Borralho… - Drug discovery today, 2013 - Elsevier
MicroRNAs (miRNAs) are pivotal post-transcriptional gene expression regulators. These
endogenous small non-coding RNAs aberrantly expressed in cancer have significant roles …

MicroRNA as a potential therapeutic molecule in cancer

J Szczepanek, M Skorupa, A Tretyn - Cells, 2022 - mdpi.com
Small noncoding RNAs, as post-translational regulators of many target genes, are not only
markers of neoplastic disease initiation and progression, but also markers of response to …

Applications of nanotechnologies for miRNA-based cancer therapeutics: current advances and future perspectives

LA Bravo-Vázquez, A Méndez-García… - … in Bioengineering and …, 2023 - frontiersin.org
MicroRNAs (miRNAs) are short (18–25 nt), non-coding, widely conserved RNA molecules
responsible for regulating gene expression via sequence-specific post-transcriptional …

Recent advances in miRNA delivery systems

I Dasgupta, A Chatterjee - Methods and protocols, 2021 - mdpi.com
MicroRNAs (miRNAs) represent a family of short non-coding regulatory RNA molecules that
are produced in a tissue and time-specific manner to orchestrate gene expression post …

microRNAs as novel therapeutics in cancer

G Romano, M Acunzo, P Nana-Sinkam - Cancers, 2021 - mdpi.com
Simple Summary Over the last few years, we have witnessed incredible advancements in
anti-tumor drug development. microRNAs, a class of small non-coding RNAs dysregulated …

miRNA nanotherapeutics for cancer

A Ganju, S Khan, BB Hafeez, SW Behrman… - Drug discovery today, 2017 - Elsevier
Highlights•MicroRNAs play a major role in cancer.•Several clinical trials with microRNA are
reported for cancer treatment.•Delivery of microRNA encounters several challenges.•We …