Lead exposure is associated with functional and microstructural changes in the healthy human brain

H Takeuchi, Y Taki, R Nouchi, R Yokoyama… - Communications …, 2021 - nature.com
Lead is a toxin known to harm many organs in the body, particularly the central nervous
system, across an individual's lifespan. To date, no study has yet investigated the …

Behavioral deficits induced by lead exposure are accompanied by serotonergic and cholinergic alterations in the prefrontal cortex

MT Mansouri, B Naghizadeh, P López-Larrubia… - Neurochemistry …, 2013 - Elsevier
The effects of long-term lead (Pb) exposure producing a blood Pb concentration of lower
than 20μg/dL, ie below that associated with overt neurological deficits in occupationally …

Decreased brain volume in adults with childhood lead exposure

KM Cecil, CJ Brubaker, CM Adler, KN Dietrich… - PLoS …, 2008 - journals.plos.org
Background Although environmental lead exposure is associated with significant deficits in
cognition, executive functions, social behaviors, and motor abilities, the neuroanatomical …

Effects of early low-level lead exposure on human brain structure, organization and functions

KM Cecil - Journal of Developmental Origins of Health and …, 2011 - cambridge.org
Advanced neuroimaging techniques offer unique insights into how childhood lead exposure
impacts the brain. Volumetric magnetic resonance imaging affords anatomical information …

The influence of age of lead exposure on adult gray matter volume

CJ Brubaker, KN Dietrich, BP Lanphear, KM Cecil - Neurotoxicology, 2010 - Elsevier
Childhood lead exposure is associated with decreased cognitive abilities and executive
functioning localized within the prefrontal cortex. Several studies have observed stronger …

Altered myelination and axonal integrity in adults with childhood lead exposure: a diffusion tensor imaging study

CJ Brubaker, VJ Schmithorst, EN Haynes, KN Dietrich… - Neurotoxicology, 2009 - Elsevier
Childhood lead exposure is associated with adverse cognitive, neurobehavioral and motor
outcomes, suggesting altered brain structure and function. The purpose of this work was to …

Chronic lead intoxication affects glial and neural systems and induces hypoactivity in adult rat

W Sansar, S Ahboucha, H Gamrani - Acta histochemica, 2011 - Elsevier
Lead is an environmental toxin and its effects are principally manifested in the brain. Glial
and neuronal changes have been described during development following chronic or acute …

A proton magnetic resonance spectroscopy study of the chronic lead effect on the basal ganglion and frontal and occipital lobes in middle-age adults

TJ Hsieh, YC Chen, CW Li, GC Liu… - Environmental …, 2009 - ehp.niehs.nih.gov
Background Lead is known to be a health hazard to the human brain and nervous system
based on data from epidemiologic studies. However, few studies have examined the …

[HTML][HTML] Cognitive impairment induced by lead exposure during lifespan: mechanisms of lead neurotoxicity

DR Ortega, DFG Esquivel, TB Ayala, B Pineda… - Toxics, 2021 - ncbi.nlm.nih.gov
Lead (Pb) is considered a strong environmental toxin with human health repercussions. Due
to its widespread use and the number of people potentially exposed to different sources of …

Cognitive Impairment Induced by lead exposure during Lifespan: mechanisms of lead neurotoxicity

D Ramírez Ortega, DF González Esquivel… - Toxics, 2021 - mdpi.com
Lead (Pb) is considered a strong environmental toxin with human health repercussions. Due
to its widespread use and the number of people potentially exposed to different sources of …