Single nucleotide variants (SNV) in the gene encoding the MET receptor tyrosine kinase
have been associated with an increased risk for autism spectrum disorders (ASD). The MET …

Background Our laboratory discovered that the gene encoding the receptor tyrosine kinase,
MET, contributes to autism risk. Expression of MET is reduced in human postmortem …

There is strong evidence for a genetic predisposition to autism and an intense interest in
discovering heritable risk factors that disrupt gene function. Based on neurobiological …

MET receptor tyrosine kinase (MET)-mediated signaling has been implicated in multiple
aspects of neocortical and cerebellar neuronal growth and maturation. A promoter functional …

Autism is a complex neurodevelopmental disorder diagnosed by impairments in social
interaction, communication, and behavioral flexibility. Autism is highly heritable, but it is not …

The validity for assigning disorder risk to an autism spectrum disorder (ASD) candidate gene
comes from convergent genetic, clinical, and developmental neurobiology data. Here, we …

Pervasive developmental disorder is a classification covering five related conditions
including the neurodevelopmental disorder Rett syndrome (RTT) and autism. Of these five …

In this chapter, we will briefly discuss recent literature on the role of MET receptor tyrosine
kinase (RTK) in brain development and how perturbation of MET signaling may alter normal …

Mutations in MECP2, encoding methyl-CpG-binding protein 2 (MeCP2), cause the
neurodevelopmental disorder Rett syndrome (RTT). Although MECP2 mutations are rare in …

Abstract Background Methyl-CpG-binding protein-2 (MeCP2) is a critical regulator for neural
development. Either loss-or gain-of-function leads to severe neurodevelopmental disorders …