Innate immune response induces positive inflammatory transducers and regulators in order
to attack pathogens, while simultaneously negative signaling regulators are transcribed to …

Phytochemicals are known to have anti-inflammatory effects in vitro and in vivo, such as in
inflammatory disease model systems. Inflammation is an essential immune response to …

The nuclear factor (NF)‐κB transcriptional system is a major effector pathway involved in
inflammation and innate immune responses. The flavonoid luteolin is found in various …

Chronic inflammation has a key role in the pathogenesis of multiple diseases that represent
major public health and financial concerns, including heart failure (HF), Alzheimer's disease …

Resveratrol was suggested to inhibit Toll-like receptor (TLR) 4-mediated activation of
nuclear factor-κB (NF-κB) and Toll/interleukin-1 receptor domain-containing adaptor …

TLRs can activate two distinct branches of downstream signaling pathways. MyD88 and
Toll/IL-1R domain-containing adaptor inducing IFN-β (TRIF) pathways lead to the …

The inflammatory response mediated by nuclear factor κB (NF-κB) signaling is essential for
host defense against pathogens. Although the regulatory mechanism of NF-κB signaling has …

Excessive activation of the TLR4 signalling pathway is critical for inflammation-associated
disorders, while negative regulators play key roles in restraining TLR4 from over-activation …

Toll-like receptors (TLRs) are a well-known family of pattern recognition receptors that play
an important role in a host immune system. TLR triggering leads to the induction of pro …

The transcription factor NF-κB is a key regulator of the cellular inflammatory and immune
response. Therefore, components of the NF-κB-activating signaling pathways are frequent …