Environmental pollution is a widespread problem, which has seriously threatened human
health and led to an increase of human diseases. Therefore, it is critical to evaluate …

Highlights•Poorly understood xenobiotic toxicants are oversaturating the environment.•
Conventional methods are incapable of accurately predicting human physiological …

Adverse effects of environmental toxicants to human health have traditionally been assayed
using in vitro assays. Organ-on-chip (OOC) is a new platform that can bridge the gaps …

The next generation of chemical toxicity testing will use organs-on-chips (OoCs)—3D
cultures of heterotypic cells with appropriate extracellular matrices to better approximate the …

The liver is a key organ that plays a pivotal role in metabolism and ensures a variety of
functions in the body, including homeostasis, synthesis of essential components, nutrient …

An increasing number of harmful environmental factors are causing serious impacts on
human health, and there is an urgent need to accurately identify the toxic effects and …

With advantageous features such as minimizing the cost, time, and sample size
requirements, organ-on-a-chip (OOC) systems have garnered enormous interest from …

Abstract Organ-on-chip (OoC) systems are microfabricated cell culture devices designed to
model functional units of human organs by harboring an in vitro generated organ surrogate …

Abstract Organ-on-chip (OoC) technology is full of engineering and biological challenges,
but it has the potential to revolutionize the Next-Generation Risk Assessment of novel …

Organ-on-a-chip systems are miniaturized microfluidic 3D human tissue and organ models
designed to recapitulate the important biological and physiological parameters of their in …