Mitogen‐activated protein kinases (MAPKs) play a key role in complex cellular processes
such as proliferation, development, differentiation, transformation and apoptosis. Mammals …

Viruses completely rely on the energy and metabolic systems of host cells for life activities.
Viral infections usually lead to cytopathic effects and host diseases. To date, there are still no …

Influenza A virus infection stimulates a wide range of virus-supportive or antiviral
mechanisms in host cells. p21-Activated kinase 1 (PAK1) is a serine/threonine kinase that …

Viral replication and pathogenesis involves many cellular protein kinases, and many specific
inhibitors of such kinase have been developed for the treatment of noninfectious diseases …

Respiratory syncytial virus (RSV) and influenza A virus are leading causes of acute lower
respiratory infectious disease. Respiratory diseases caused by RSV and influenza A virus …

The mitogen-activated protein kinase (MAPK) family is responsible for important signalling
pathways which regulate cell activation, differentiation, apoptosis and immune responses …

Objective: To analyze a novel compound, which inhibits serine-threonine protein kinase
p38, for its possible bioactivity against HIV-1 infection. Methods: Proteins involved in cellular …

Stress-activated protein kinases (SAPKs), consisting of c-Jun N-terminal kinase (JNK) and
p38 mitogen-activated protein kinase (p38 MAPK), are activated upon various …

Viruses are obligate intracellular parasites; they heavily depend on the host cell machinery
to effectively replicate and produce new progeny virus particles. Following viral infection …

Mitogen-activated protein kinases (MAPKs) play critical regulatory roles in the production of
the pro-inflammatory cytokines and downstream signaling events which lead to …