SFTSV Gn‐Head mRNA vaccine confers efficient protection against lethal viral challenge

D Kim, CJ Lai, I Cha, S Kang, WS Yang… - Journal of Medical …, 2023 - Wiley Online Library
Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick‐borne
virus, causing thrombocytopenia and hemorrhagic fever, with a fatality rate ranging from …

mRNA vaccine encoding Gn provides protection against severe fever with thrombocytopenia syndrome virus in mice

JY Kim, K Jeon, SI Park, YJ Bang, HJ Park, HW Kwak… - npj Vaccines, 2023 - nature.com
We developed a promising mRNA vaccine against severe fever with thrombocytopenia
syndrome (SFTS), an infectious disease caused by the SFTS virus that is primarily …

Comparative analysis of the efficacy of vaccines using structural protein subunits of the severe fever with thrombocytopenia syndrome virus

S Kim, K Jeon, H Choi, DE Jeong, JG Kang… - Frontiers in …, 2024 - frontiersin.org
The severe fever with thrombocytopenia syndrome virus (SFTSV) represents a significant
emerging health threat as a tick-borne pathogen that causes SFTS, with mortality rates …

Neutralizing mAbs against SFTS virus Gn protein show strong therapeutic effects in an SFTS animal model

M Shimojima, S Sugimoto, K Umekita, T Onodera… - Viruses, 2022 - mdpi.com
Severe fever with thrombocytopenia syndrome (SFTS) is an infectious disease with a high
case fatality rate caused by the SFTS virus, and currently there are no approved specific …

Immunization with recombinant SFTSV/NSs protein does not promote virus clearance in SFTSV-infected C57BL/6J mice

R Liu, DD Huang, JY Bai, L Zhuang, QB Lu… - Viral …, 2015 - liebertpub.com
The severe fever with thrombocytopenia syndrome (SFTS), caused by a novel Phlebovirus
in the Bunyaviridae family named SFTS virus (SFTSV), is an emerging hemorrhagic fever …

[HTML][HTML] A single-domain antibody inhibits SFTSV and mitigates virus-induced pathogenesis in vivo

X Wu, Y Li, B Huang, X Ma, L Zhu, N Zheng, S Xu… - JCI insight, 2020 - ncbi.nlm.nih.gov
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a novel tick-borne
bunyavirus that recently emerged in East Asian countries. SFTS is characterized by high …

Development of a SFTSV DNA vaccine that confers complete protection against lethal infection in ferrets

JE Kwak, YI Kim, SJ Park, MA Yu, HI Kwon, S Eo… - Nature …, 2019 - nature.com
Although the incidence of severe fever with thrombocytopenia syndrome virus (SFTSV)
infection has increased from its discovery with a mortality rate of 10–20%, no effective …

Single dose of a rVSV-based vaccine elicits complete protection against severe fever with thrombocytopenia syndrome virus

F Dong, D Li, D Wen, S Li, C Zhao, Y Qi, RK Jangra… - npj Vaccines, 2019 - nature.com
Severe fever with thrombocytopenia virus (SFTSV) is an emerging tick-borne phlebovirus
that causes lethal human disease, for which there are no licensed antiviral vaccines or …

Vaccination with single plasmid DNA encoding IL-12 and antigens of severe fever with thrombocytopenia syndrome virus elicits complete protection in IFNAR …

JG Kang, K Jeon, H Choi, Y Kim, HI Kim… - PLoS neglected …, 2020 - journals.plos.org
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne disease
caused by SFTS virus (SFTSV) infection. Despite a gradual increase of SFTS cases and …

Cross-genotype protection of live-attenuated vaccine candidate for severe fever with thrombocytopenia syndrome virus in a ferret model

KM Yu, SJ Park, MA Yu, YI Kim… - Proceedings of the …, 2019 - National Acad Sciences
Severe fever with thrombocytopenia syndrome (SFTS) virus (SFTSV) is an emerging tick-
borne virus classified within the Banyangvirus genus. SFTS disease has been reported …