β-carboline derivative Z86 attenuates colorectal cancer cell proliferation and migration by directly targeting PI3K
S Nie, L Chang, Y Huang, H Zhou, Q Yang… - Natural Products and …, 2024 - Springer
Abstract Phosphoinositide 3-kinase (PI3Ks) are lipid kinases widely involved in cell
proliferation, metastasis and differentiation. Constitutive activation of the PI3K/Akt/mTOR …
proliferation, metastasis and differentiation. Constitutive activation of the PI3K/Akt/mTOR …
ZDQ-0620, a novel phosphatidylinositol 3-kinase inhibitor, inhibits colorectal carcinoma cell proliferation and suppresses angiogenesis by attenuating PI3K/AKT …
X Qin, M Liu, C Xu, B Xing, X Xu, Y Wu, H Ding… - Frontiers in …, 2022 - frontiersin.org
The PI3K/AKT pathway plays a central role in human cancers, aberrant activation of this
pathway is associated with tumorigenesis, cancer progression and angiogenesis. Based on …
pathway is associated with tumorigenesis, cancer progression and angiogenesis. Based on …
A novel PI3K axis selective molecule exhibits potent tumor inhibition in colorectal carcinogenesis
A Hussain, AK Qazi, N Mupparapu… - Molecular …, 2016 - Wiley Online Library
Phosphatidylinositol‐3‐kinase (PI3K) pathway deregulation is responsible for initiation,
chemo‐resistance, and poor prognosis of colorectal cancer (CRC). Therefore, PI3K pathway …
chemo‐resistance, and poor prognosis of colorectal cancer (CRC). Therefore, PI3K pathway …
Targeted inhibition of the phosphoinositide 3-kinase impairs cell proliferation, survival, and invasion in colon cancer
F Yang, JY Gao, H Chen, ZH Du, XQ Zhang… - OncoTargets and …, 2017 - Taylor & Francis
Background Colon cancer is the third most common cancer in the world, and its metastasis
and drug resistance are challenging for its effective treatment. The PI3K/Akt/mTOR pathway …
and drug resistance are challenging for its effective treatment. The PI3K/Akt/mTOR pathway …
Inhibition of PI3K/AKT signaling using BKM120 reduced the proliferation and migration potentials of colorectal cancer cells and enhanced cisplatin-induced …
Background Although extensive efforts have been made to improve the treatment of
colorectal cancer (CRC) patients, the prognosis for these patients remains poor. A wide …
colorectal cancer (CRC) patients, the prognosis for these patients remains poor. A wide …
HS-116, a novel phosphatidylinositol 3-kinase inhibitor induces apoptosis and suppresses angiogenesis of hepatocellular carcinoma through inhibition of the PI3K …
KH Jung, MJ Choi, S Hong, H Lee, SW Hong… - Cancer letters, 2012 - Elsevier
The phosphatidylinositol 3-kinase (PI3K) pathway plays a central role in cell proliferation
and survival of human cancers. As PI3K is active in many cancer patients, resulting in cancer …
and survival of human cancers. As PI3K is active in many cancer patients, resulting in cancer …
Design, synthesis and bioevaluation of PI3Kα-selective inhibitors as potential colorectal cancer drugs
XM Zheng, YS Chen, YJ Ban, YJ Wang… - European Journal of …, 2023 - Elsevier
The dysregulation of the phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin
signaling pathway has been implicated in various human cancers, and isoform-selective …
signaling pathway has been implicated in various human cancers, and isoform-selective …
PI3K/Akt/mTOR pathway as a therapeutic target for colorectal cancer: a review of preclinical and clinical evidence
A Narayanankutty - Current drug targets, 2019 - ingentaconnect.com
Background: Phosphoinositide 3-kinase (PI3Ks) is a member of intracellular lipid kinases
and involved in the regulation of cellular proliferation, differentiation and survival …
and involved in the regulation of cellular proliferation, differentiation and survival …
PI3K: a potential therapeutic target for cancer
Y Chen, BC Wang, Y Xiao - Journal of cellular physiology, 2012 - Wiley Online Library
Abstract Phosphatidylinositol 3‐kinase (PI3K), one member of lipid kinase family, has been
demonstrated to play a key role in regulating cell proliferation, adhesion, survival, and …
demonstrated to play a key role in regulating cell proliferation, adhesion, survival, and …
The PI3K Pathway in Colorectal Cancers
Abstract Phosphoinositide 3-kinase (PI3K) belongs to the intracellular lipid kinases family
involved in diverse physiological processes, including proliferation, apoptosis, growth, and …
involved in diverse physiological processes, including proliferation, apoptosis, growth, and …