Highlights•NK cell education is endowed by independently-segregating polygenic KIR and
HLA which, combined, enable diverse effector functions.•Education counterbalances each …

The functional capacities of natural killer (NK) cells differ within and between individuals,
reflecting considerable genetic variation.'Licensing/arming','disarming', and 'tuning'are …

Natural killer (NK) cells are fast-acting and versatile lymphocytes that are critical effectors of
innate immunity, adaptive immunity, and placental development. Controlling NK cell function …

Natural killer (NK) cells have vital functions in human immunity and reproduction. In the
innate and adaptive immune responses to infection, particularly by viruses, NK cells respond …

Natural killer (NK) cells are lymphocytes of the innate immune system that are critical in host
defense and immune regulation. They are activated or inhibited through the ligation of …

Natural killer (NK) cells are functionally tuned by education via killer cell immunoglobulin
receptors (KIRs) interacting with HLA class I molecules. We examined the effect of KIR gene …

Natural killer cells constitute a potent, rapid part of the innate immune response to infection
or transformation, and also generate a link to priming of adaptive immunity. Their function …

Natural killer (NK) cells are the predominant innate lymphocyte subsets that mediate anti-
tumor and anti-viral responses, and therefore possess promising clinical utilization. NK cells …

Natural killer (NK) cells are more than simple killers and have been implicated in control and
clearance of malignant and virally infected cells, regulation of adaptive immune responses …

Background Human natural killer (NK) cell activity is regulated by a family of killer cell
immunoglobulin-like receptors (KIRs) that bind human leukocyte antigen (HLA) class I …