The ORF6, ORF8 and nucleocapsid proteins of SARS-CoV-2 inhibit type I interferon signaling pathway

JY Li, CH Liao, Q Wang, YJ Tan, R Luo, Y Qiu, XY Ge - Virus research, 2020 - Elsevier
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel human
coronavirus causing the pandemic of severe pneumonia (Coronavirus Disease 2019 …

Structural analysis of SARS-CoV-2 ORF8 protein: pathogenic and therapeutic implications

A Valcarcel, A Bensussen, ER Álvarez-Buylla… - Frontiers in …, 2021 - frontiersin.org
Current therapeutic strategies and vaccines against SARS-CoV-2 are mainly focused on the
Spike protein despite there are other viral proteins with important roles in COVID-19 …

[HTML][HTML] The role of SARS-CoV-2 accessory proteins in immune evasion

M Zandi, M Shafaati, D Kalantar-Neyestanaki… - Biomedicine & …, 2022 - Elsevier
Many questions on the SARS-CoV-2 pathogenesis remain to answer. The SARS-CoV-2
genome encodes some accessory proteins that are essential for infection. Notably …

SARS-CoV-2 ORF8 forms intracellular aggregates and inhibits IFNγ-induced antiviral gene expression in human lung epithelial cells

H Geng, S Subramanian, L Wu, HF Bu… - Frontiers in …, 2021 - frontiersin.org
Infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes
COVID-19, a disease that involves significant lung tissue damage. How SARS-CoV-2 …

[HTML][HTML] A unique view of SARS-CoV-2 through the lens of ORF8 protein

SS Hassan, AAA Aljabali, PK Panda, S Ghosh… - Computers in biology …, 2021 - Elsevier
Immune evasion is one of the unique characteristics of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) attributed to its ORF8 protein. This protein modulates the …

The ORF8 protein of SARS-CoV-2 induced endoplasmic reticulum stress and mediated immune evasion by antagonizing production of interferon beta

F Rashid, EE Dzakah, H Wang, S Tang - Virus research, 2021 - Elsevier
The open reading frame 8 (orf8) is an accessory protein of SARS-CoV-2. It has 121 amino
acids with two genotypes, orf8L and orf8S. In this study, we overexpressed the orf8L and …

SARS-CoV-2 nsp13, nsp14, nsp15 and orf6 function as potent interferon antagonists

CK Yuen, JY Lam, WM Wong, LF Mak… - Emerging microbes & …, 2020 - Taylor & Francis
ABSTRACT The Coronavirus disease 2019 (COVID-19), which is caused by the novel SARS-
CoV-2 virus, is now causing a tremendous global health concern. Since its first appearance …

[HTML][HTML] ORF3a protein of severe acute respiratory syndrome coronavirus 2 inhibits interferon-activated janus kinase/signal transducer and activator of transcription …

R Wang, X Yang, M Chang, Z Xue, W Wang… - Frontiers in …, 2021 - frontiersin.org
Coronavirus disease 2019 (COVID-19) has caused a crisis to global public health since its
outbreak at the end of 2019. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV …

Activation of NF-κB and induction of proinflammatory cytokine expressions mediated by ORF7a protein of SARS-CoV-2

CM Su, L Wang, D Yoo - Scientific reports, 2021 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent for
coronavirus disease 2019 (COVID-19) that emerged in human populations recently …

[PDF][PDF] ORF8 contributes to cytokine storm during SARS-CoV-2 infection by activating IL-17 pathway

X Lin, B Fu, S Yin, Z Li, H Liu, H Zhang, N Xing, Y Wang… - Iscience, 2021 - cell.com
Recently, COVID-19 caused by the novel coronavirus SARS-CoV-2 has brought great
challenges to the world. More and more studies have shown that patients with severe …