A central goal of systems biology is to elucidate the structural and functional architecture of
the cell. To this end, large and complex networks of molecular interactions are being rapidly …

Complex cellular processes are modular and are accomplished by the concerted action of
functional modules (Ravasz et al., Science 2002; 297: 1551–1555; Hartwell et al., Nature …

The era of genome sequencing has produced long lists of the molecular parts from which
cellular machines are constructed. A fundamental goal in systems biology is to understand …

Molecular interaction data plays an important role in understanding biological processes at
a modular level by providing a framework for understanding cellular organization, functional …

The completion of genome sequences and subsequent high-throughput mapping of
molecular networks have allowed us to study biology from the network perspective …

Background Biological systems can be modeled as complex network systems with many
interactions between the components. These interactions give rise to the function and …

Background Graphical models of network associations are useful for both visualizing and
integrating multiple types of association data. Identifying modules, or groups of functionally …

By combining the pairwise interactions between proteins, as predicted by the conserved co-
occurrence of their genes in operons, we obtain protein interaction networks. Here we study …

Deciphering heterogeneous cellular networks with embedded modules is a great challenge
of current systems biology. Experimental and computational studies construct complex …

Proteins, nucleic acids, and small molecules form a dense network of molecular interactions
in a cell. Molecules are nodes of this network, and the interactions between them are edges …