The progression of ovarian cancer, from cell transformation through invasion of normal
tissue, relies on communication between tumor cells and their adjacent stromal …

Stromal cells are essential for the progression of many cancers including ovarian tumors.
Stromal cell-epithelial cell interactions are important for tumor development, growth …

The tumor microenvironment, consisting of stromal myofibroblasts, endothelial cells, and
leukocytes, is growingly perceived to be a major contributor to the pathogenesis and …

Ovarian cancer is a histologically, clinically, and molecularly diverse disease with a five-year
survival rate of less than 30%. It has been estimated that approximately 21,980 new cases of …

Ovarian adenocarcinoma is characterized by a late detection, dissemination of cancer cells
into the whole peritoneum, and the frequent acquisition of chemoresistance. If these …

Ovarian cancer is the most lethal gynecologic malignancy, and patient prognosis has not
improved significantly over the last several decades. In order to improve therapeutic …

Background The clinical significance of hematogenous and lymphatic metastasis in ovarian
cancer has been increasingly addressed, as it plays an imperative role in the formation of …

Although stromal cell signaling has been shown to play a significant role in the progression
of many cancers, relatively little is known about its importance in modulating ovarian cancer …

Ovarian cancer (OVAC) remains the most lethal gynecological malignancy; it is ranked fifth
among the most common types of cancer that affect women worldwide. Several aspects of …

Extensive research has been conducted over several decades understanding the genetic
changes that occur in normal cells to promote them towards a transformed state. However, it …