Background: Schizophrenia is a serious mental illness that affects more than 21 million
people worldwide. Both genetics and the environment play a role in its etiology and …

Animal models are extremely useful tools in defining pathogenesis and treatment of human
disease. Creating adequate animal models of complex neuropsychiatric disorders such as …

Animal models of schizophrenia may increase the understanding of the neurological
abnormalities associated with the disorder and aid in the development of rational …

A devastating psychiatric disorder, schizophrenia is characterized by three major symptoms,
positive and negative symptoms and cognitive deficit. Almost all current therapeutic drugs for …

Schizophrenia may well represent one of the most heterogenous mental disorders in human
history. This heterogeneity encompasses (1) etiology; where numerous putative genetic and …

The strategies used in preclinical research in schizophrenia have evolved from experiments
focused on the pharmacology of existing antipsychotic or psychotomimetic drugs to the …

Cognitive dysfunction is a core aspect of schizophrenia that constitutes a major obstacle
toward reintegration of patients into society. Although multiple cognitive deficits are evident …

Animal models are an essential initial phase in the discovery of novel drugs to treat
psychiatric disorders. At the sixth Measurement and Treatment Research to Improve …

Developing reliable, predictive animal models for complex psychiatric disorders, such as
schizophrenia, is essential to increase our understanding of the neurobiological basis of the …

Cross-validated animal models for schizophrenia are crucial to comprehend the cause,
pathophysiology, and behavioral and biological features of the disease, to advance …