Abstract The West Africa Ebola outbreak was the largest outbreak ever recorded, with over
28,000 reported infections; this devastating epidemic emphasized the need to understand …

Ebola virus outbreaks, such as the 2014 Makona epidemic in West Africa, are episodic and
deadly. Filovirus antivirals are currently not clinically available. Our findings suggest …

The VP35 protein of Zaire Ebola virus is an essential component of the viral RNA
polymerase complex and also functions to antagonize the cellular type I interferon (IFN) …

Ebola hemorrhagic fever is a rapidly progressing acute febrile illness characterized by high
virus replication, severe immunosuppression, and case fatalities of ca. 80%. Inhibition of …

Ebolaviruses cause hemorrhagic fever with up to 90% lethality and in fatal cases, are
characterized by early suppression of the host innate immune system. One of the proteins …

Dysregulated host immune responses: can we alter the outcome? As with other viral
infections, initial induction of type 1 IFNs are likely to elicit subsequent productive immune …

The interferon (IFN) system is the first line of defense against viral infections. Evasion of IFN
signaling by Ebola viral protein 24 (VP24) is a critical event in the pathogenesis of the …

Ebola viruses (EBOVs) cause rare but highly fatal outbreaks of viral hemorrhagic fever in
humans, and approved treatments for these infections are currently lacking. The Ebola VP35 …

Ebola virus VP35 contains a C-terminal cluster of basic amino acids required for double-
stranded RNA (dsRNA) binding and inhibition of interferon regulatory factor 3 (IRF3). VP35 …

Zaire ebolavirus causes a rapidly progressing hemorrhagic disease with high mortality.
Identification of the viral virulence factors that contribute to the severity of disease induced by …