The phosphoinositide‐specific phospholipase C (PLC) enzyme family consists of six classes
of proteins that hydrolyze membrane phosphoinositides in response to various stimuli …

Receptor-initiated phospholipase C activation and generation of IP3 and DAG are important
common triggers for a diversity of signal transduction processes in many cell types …

The roles of phosphoinositide-specific phospholipase C (PLC) have been extensively
investigated in diverse cell lines and pathological conditions. Among the PLC isozmes …

Phospholipase C (PLC) is a key enzyme in phosphoinositide metabolism. PLC hydrolyses
phosphatidylinositol 4, 5-bis-phosphate to generate two second messengers, inositol 1, 4, 5 …

Phospholipase C (PLC) enzymes convert the membrane phospholipid phosphatidylinositol-
4, 5-bisphosphate (PIP2) into inositol-1, 4, 5-triphosphate (IP3) and diacylglycerol (DAG) …

Phosphoinositide-specific phospholipase C (PLC) hydrolyzes phosphatidylinositol-4, 5-
bisphosphate (PIP2) to produce inositol-1, 4, 5-triphosphate (IP3) and diacylglycerol (DAG) …

Phospholipase C-ε (PLCε) integrates signaling from G-protein coupled receptors (GPCRs) to
downstream kinases to regulate a broad range of biological and pathophysiological …

Phospholipase C (PLC) β isoforms are implicated in various physiological processes and
pathologies. However, mechanistic insight into the localization and activation of each of the …

Phospholipase C (PLC) enzymes convert phosphatidylinositol-4, 5-bisphosphate into the
second messengers diacylglycerol and inositol-1, 4, 5-triphosphate. The production of these …

Phospholipase C (PLC) plays pivotal roles in regulating various cellular functions by
metabolizing phosphatidylinositol 4, 5-bisphosphate in the plasma membrane. This process …