Chronic kidney disease (CKD) is determined by an interplay of monogenic, polygenic, and
environmental risks. Autosomal dominant polycystic kidney disease (ADPKD) and COL4A …

Background: Chronic kidney disease (CKD) is a genetically complex disease determined by
an interplay of monogenic, polygenic, and environmental risks. Most forms of monogenic …

Numerous genes for monogenic kidney diseases with classical patterns of inheritance, as
well as genes for complex kidney diseases that manifest in combination with environmental …

Background Studies have identified many common genetic associations that influence renal
function and all-cause CKD, but these explain only a small fraction of variance in these traits …

Genome-wide association studies (GWAS) have identified> 100 loci of chronic kidney
disease-defining traits (CKD-dt). Molecular mechanisms underlying these associations …

A new study reports that genome-wide polygenic risk scores can identify individuals at risk of
common complex diseases, such as coronary artery disease or type 2 diabetes, with …

Kidney diseases constitute a serious public health burden worldwide, with substantial
associated morbidity and mortality. The role of a genetic contribution to kidney disease is …

Genome-wide association studies (GWASs) have advanced our understanding of the
genetic basis for common renal diseases, including chronic kidney disease (CKD) and …

Chronic kidney disease (CKD) is a common complex condition associated with high
morbidity and mortality. Polygenic prediction could enhance CKD screening and prevention; …

Over the past decade, genome-wide association studies (GWAS) have considerably
improved our understanding of the genetic basis of kidney function and disease. Population …