Bacterial lipopolysaccharide triggers human caspase-4 (murine caspase-11) to cleave
gasdermin-D and induce pyroptotic cell death. How lipopolysaccharide sequestered in the …

The human non-canonical inflammasome controls caspase-4 activation and gasdermin-D-
dependent pyroptosis in response to cytosolic bacterial lipopolysaccharide (LPS). Since …

The gamma-interferon (IFNγ)-inducible guanylate-binding proteins (GBPs) promote host
defense against gram-negative cytosolic bacteria in part through the induction of an …

Intracellular lipopolysaccharide from Gram-negative bacteria including Escherichia coli,
Salmonella typhimurium, Shigella flexneri, and Burkholderia thailandensis activates mouse …

Interferon-inducible guanylate-binding proteins (GBPs) promote cell-intrinsic defense
through host cell death. GBPs target pathogens and pathogen-containing vacuoles and …

The guanylate binding protein (GBP) family of interferon‐inducible GTP ases promotes
antimicrobial immunity and cell death. During bacterial infection, multiple mouse Gbps …

Abstract Inflammatory caspase‐11 (rodent) and caspases‐4/5 (humans) detect the Gram‐
negative bacterial component LPS within the host cell cytosol, promoting activation of the …

Inflammasomes are cytosolic signaling complexes capable of sensing microbial ligands to
trigger inflammation and cell death responses. Here, we show that guanylate-binding …

IFN receptor signaling induces cell-autonomous immunity to infections with intracellular
bacterial pathogens. Here, we demonstrate that IFN-inducible guanylate binding protein …

Abstract Inflammatory caspases (caspase-1,-4,-5 and-11) are critical for innate defences.
Caspase-1 is activated by ligands of various canonical inflammasomes, and caspase-4,-5 …