Glucose metabolism of TAMs in tumor chemoresistance and metastasis

J Liu, X Cao - Trends in Cell Biology, 2023 - cell.com
Tumor-associated macrophages (TAMs) are critical in promoting tumor progression and
therapeutic resistance. In adapting to metabolic changes in the tumor microenvironment …

Glucose metabolism: the metabolic signature of tumor associated macrophage

Q Zhang, J Wang, DK Yadav, X Bai… - Frontiers in Immunology, 2021 - frontiersin.org
Macrophages exist in most tissues of the body, where they perform various functions at the
same time equilibrating with other cells to maintain immune responses in numerous …

The Metabolic Features of Tumor‐Associated Macrophages: Opportunities for Immunotherapy?

SS Mojsilovic, S Mojsilovic, VH Villar… - Analytical Cellular …, 2021 - Wiley Online Library
Besides transformed cells, the tumors are composed of various cell types that contribute to
undesirable tumor progression. Tumor‐associated macrophages (TAMs) are the most …

Increased glucose metabolism in TAMs fuels O-GlcNAcylation of lysosomal Cathepsin B to promote cancer metastasis and chemoresistance

Q Shi, Q Shen, Y Liu, Y Shi, W Huang, X Wang, Z Li… - Cancer cell, 2022 - cell.com
How glucose metabolism remodels pro-tumor functions of tumor-associated macrophages
(TAMs) needs further investigation. Here we show that M2-like TAMs bear the highest …

Macrophages and metabolism in the tumor microenvironment

I Vitale, G Manic, LM Coussens, G Kroemer, L Galluzzi - Cell metabolism, 2019 - cell.com
Tumor-associated macrophages (TAMs) constitute a plastic and heterogeneous cell
population of the tumor microenvironment (TME) that can account for up to 50% of some …

The role of metabolic plasticity of tumor-associated macrophages in shaping the tumor microenvironment immunity

MN Hasan, O Capuk, SM Patel, D Sun - Cancers, 2022 - mdpi.com
Simple Summary Tumor associated macrophages (TAMs) support disease progression by
providing tumor cells cytokines and chemokines necessary for malignant growth and …

Glycolysis regulation in tumor‐associated macrophages: Its role in tumor development and cancer treatment

G Jiang, J Hong, L Sun, H Wei, W Gong… - … Journal of Cancer, 2024 - Wiley Online Library
Tumor‐associated macrophages constitute the main cell population in the tumor
microenvironment and play a crucial role in regulating the microenvironment composition …

Metabolic interplay: tumor macrophages and regulatory T cells

S Vilbois, Y Xu, PC Ho - Trends in Cancer, 2024 - cell.com
The tumor microenvironment (TME) contains a complex cellular ecosystem where cancer,
stromal, vascular, and immune cells interact. Macrophages and regulatory T cells (Tregs) …

Metabolic regulation of tumor-associated macrophage heterogeneity: insights into the tumor microenvironment and immunotherapeutic opportunities

Y Qian, Y Yin, X Zheng, Z Liu, X Wang - Biomarker Research, 2024 - Springer
Tumor-associated macrophages (TAMs) are a heterogeneous population that play diverse
functions in tumors. Their identity is determined not only by intrinsic factors, such as origins …

[HTML][HTML] Metabolic changes in tumor cells and tumor-associated macrophages: a mutual relationship

RT Netea-Maier, JWA Smit, MG Netea - Cancer letters, 2018 - Elsevier
In order to adapt to the reduced availability of nutrients and oxygen in the tumor
microenvironment and the increased requirements of energy and building blocks necessary …