Alterations in cardiac energy metabolism contribute to the severity of heart failure. However,
the energy metabolic changes that occur in heart failure are complex and are dependent not …

Fatty acids are the main substrates used by mitochondria to provide myocardial energy
under normal conditions. During heart remodeling, however, the fuel preference switches to …

The chronically failing heart has been shown to be metabolically abnormal, in both animal
models and in patients. Little data are available on the rate of myocardial glucose, lactate …

Despite recent advances in therapy, heart failure remains a major cause of mortality and
morbidity and is a growing healthcare burden worldwide. Alterations in myocardial energy …

To maintain its high energy demand the heart is equipped with a highly complex and
efficient enzymatic machinery that orchestrates ATP production using multiple energy …

The failing heart has an increased metabolic demand and at the same time suffers from
impaired energy efficiency, which is a detrimental combination. Therefore, therapies …

The incidence and prevalence of heart failure have increased significantly over the past few
decades. Available data suggest that patients with heart failure independent of the aetiology …

Alterations in cardiac energy metabolism contribute to the severity of heart failure. However,
the energy metabolic changes that occur in heart failure are complex, and are dependent …

Abnormalities of cardiac energy metabolism make an important contribution to chronic heart
failure. This review summarizes the main events in cardiac energy metabolism, discusses …

Despite the fact that the heart requires huge amounts of energy to sustain contractile
function, it has limited energy reserves and must therefore continually produce large …