Previous attempts to identify a unified theory of brain serotonin function have largely failed to
achieve consensus. In this present synthesis, we integrate previous perspectives with new …

Serotonin, one of the first neurotransmitters to be identified, is an evolutionarily old molecule
that is highly conserved across the animal kingdom, and widely used throughout the brain …

The neurotransmitter serotonin (5-hdroxytryptamine; 5-HT) has been implicated in the
pathophysiology and treatment of major depression since the serendipitous discovery of …

Executive function entails the interplay of a group of cognitive processes enabling the
individual to anticipate consequences, attain self-control, and undertake appropriate goal …

The therapeutic effects induced by serotonin-selective reuptake inhibitor (SSRI)
antidepressants are initially triggered by blocking the serotonin transporter and rely on long …

The enhancement of central serotonin system function underlies the therapeutic effects of
selective serotonin reuptake inhibitors (SSRIs), which have become the most commonly …

The serotonergic system extends throughout the central nervous system (CNS) and the
gastrointestinal (GI) tract. In the CNS, serotonin (5-HT, 5-hydroxytryptamine) modulates a …

Psychiatric disorders represent a large economic burden in modern societies. However,
pharmacological treatments are still far from optimal. Drugs used in the treatment of major …

Abstract Serotonin (5-hydroxytryptamine; 5-HT) has been implicated in a large number of
psychophysiologic processes including the regulation of sleep, appetite, mood, aggression …

Background: Symptoms of cognitive impairment such as poor concentration, memory loss
and difficulty with decision making are prevalent in patients with depression, but currently …