The complement system is a key element of the innate immune system, and the production
of complement components can be divided into central (hepatic) and peripheral …

After decades of neglect, complement has been rediscovered as a potent mediator and
diagnostic indicator of inflammation and rejection in organ transplants. In part, this reflects a …

The complement system plays a complex role in transplantation, beginning with effects on
reperfusion injury and continuing with stimulation of the adaptive immune response. Recent …

Recent advances in complement biology The complement system, traditionally considered a
central arm of innate immunity, consists a set of soluble and cell surface proteins including …

Accumulating evidence suggests that innate immunity interacts with the adaptive immune
system to identify potentially harmful antigens and eliminate them from the host. A central …

The current immunosuppressive protocols used in transplant recipients have improved short-
term outcomes, but long-term allograft failure remains an important clinical problem. Greater …

Until recently, the only known condition in which complement could mediate transplant injury
was the rare occurrence of antibody-mediated rejection, in which the original concept of …

The mechanism of rejection in solid organ transplantation is influenced by the initial
inflammatory response and subsequent adaptive allo-immune response, both of which have …

Complement is a multifunctional system of receptors and regulators as well as effector
molecules. Both the pathogenic and diagnostic power of complement is based on the …

In transplantation, activation of complement has largely been equated to antibody-mediated
rejection, but complement is also important in recognition of apoptotic and necrotic cells as …