The human telomerase gene (hTERT) is repressed in most somatic cells. How transcription
factors activate the hTERT promoter in its repressive chromatin environment is unknown …

Human telomerase gene hTERT is important for cancer and aging. hTERT promoter is
regulated by multiple transcription factors (TFs) and its activity is dependent on the …

Since induction of hTERT expression and subsequent telomerase activation play a critical
role in the multistep process of tumorigenesis, a better understanding of hTERT regulation …

Human telomerase reverse transcriptase (hTERT) underlies cancer cell immortalization, and
the expression of hTERT is regulated strictly at the gene transcription. Here, we report that …

Telomerase maintains telomeres to preclude cell senescence. It remains elusive how
telomerase activity is repressed in differentiated cells, but retained at high levels in stem …

Most human cancers express telomerase but its activity is highly variable and regulated by
complex mechanisms. Recently, we have proposed that Ets proteins may be important for …

Upregulation of human telomerase reverse transcriptase (hTERT) transcription accounts for
the immortalization of greater than 85% of all human tumor cells. However, the mechanism …

Telomerase is a regulated enzyme and its activity is tightly associated with cell proliferation.
The mechanisms of this association are unclear, but specific growth factors may regulate …

The enzyme telomerase maintains telomeres (ends of chromosomes) by synthesizing
telomeric DNA at each end of the chromosomes. Its association with telomeres has …

Point mutations within the TERT promoter are the most recurrent somatic noncoding
mutations identified across different cancer types, including glioblastoma, melanoma …