Toward personalized computer simulation of breast cancer treatment: A multiscale pharmacokinetic and pharmacodynamic model informed by multitype patient data
The usefulness of mechanistic models to disentangle complex multiscale cancer processes,
such as treatment response, has been widely acknowledged. However, a major barrier for …
such as treatment response, has been widely acknowledged. However, a major barrier for …
Prediction of drug response in breast cancer using integrative experimental/computational modeling
Nearly 30% of women with early-stage breast cancer develop recurrent disease attributed to
resistance to systemic therapy. Prevailing models of chemotherapy failure describe three …
resistance to systemic therapy. Prevailing models of chemotherapy failure describe three …
[HTML][HTML] Precision medicine with imprecise therapy: computational modeling for chemotherapy in breast cancer
Medical oncology is in need of a mathematical modeling toolkit that can leverage clinically-
available measurements to optimize treatment selection and schedules for patients. Just as …
available measurements to optimize treatment selection and schedules for patients. Just as …
Multi-scale modeling in clinical oncology: opportunities and barriers to success
Hierarchical processes spanning several orders of magnitude of both space and time
underlie nearly all cancers. Multi-scale statistical, mathematical, and computational …
underlie nearly all cancers. Multi-scale statistical, mathematical, and computational …
Integrating multiscale modeling with drug effects for cancer treatment
In this paper, we review multiscale modeling for cancer treatment with the incorporation of
drug effects from an applied system's pharmacology perspective. Both the classical …
drug effects from an applied system's pharmacology perspective. Both the classical …
Mathematical modeling of cancer progression and response to chemotherapy
S Sanga, JP Sinek, HB Frieboes, M Ferrari… - Expert review of …, 2006 - Taylor & Francis
The complex, constantly evolving and multifaceted nature of cancer has made it difficult to
identify unique molecular and pathophysiological signatures for each disease variant …
identify unique molecular and pathophysiological signatures for each disease variant …
Computational simulations of tumor growth and treatment response: Benefits of high-frequency, low-dose drug regimens and concurrent vascular normalization
Implementation of effective cancer treatment strategies requires consideration of how the
spatiotemporal heterogeneities within the tumor microenvironment (TME) influence tumor …
spatiotemporal heterogeneities within the tumor microenvironment (TME) influence tumor …
Using computer simulations for evaluating the efficacy of breast cancer chemotherapy protocols
E Shochat, D Hart, Z Agur - Mathematical Models and Methods in …, 1999 - World Scientific
The fundamental strategy of chemotherapy is to maximize tumor eradication within the limits
of tolerable toxicity to the organism. To demonstrate the use of mathematical models in …
of tolerable toxicity to the organism. To demonstrate the use of mathematical models in …
Modeling multi-drug chemotherapy: tailoring treatment to individuals
SN Gardner - Journal of theoretical biology, 2002 - Elsevier
Background: Predicting and tailoring optimal cancer treatments presents a major challenge.
Methods: A computational model (kinetically tailored treatment, or KITT model) is developed …
Methods: A computational model (kinetically tailored treatment, or KITT model) is developed …
Computer model challenges breast cancer treatment strategy
MW Retsky, DE Swartzendruber, PD Bame… - Cancer …, 1994 - Taylor & Francis
The breast cancer treatment failure rate remains unacceptably high. The current breast
cancer treatment paradigm, based primarily on Gompertzian kinetics and animal models …
cancer treatment paradigm, based primarily on Gompertzian kinetics and animal models …