Transcriptomic sex differences in postmortem brain samples from patients with psychiatric disorders
Many psychiatric disorders exhibit sex differences, but the underlying mechanisms remain
poorly understood. We analyzed transcriptomics data from 2160 postmortem adult prefrontal …
poorly understood. We analyzed transcriptomics data from 2160 postmortem adult prefrontal …
Sex and cell-specific gene expression in corticolimbic brain regions associated with psychiatric disorders revealed by bulk and single-nuclei RNA sequencing
E Fitzgerald, DM Arcego, MJ Shen, N O'Toole, X Wen… - …, 2023 - thelancet.com
Background There are sex-specific differences in the prevalence, symptomology and course
of psychiatric disorders. However, preclinical models have primarily used males, such that …
of psychiatric disorders. However, preclinical models have primarily used males, such that …
Transcriptome analysis of male–female differences in prefrontal cortical development
CS Weickert, M Elashoff, AB Richards, D Sinclair… - Molecular …, 2009 - nature.com
Human neuropsychiatric disorders that involve the prefrontal cortex show gender differences
in age of onset, prevalence and symptomatology. Gender dimorphisms in human-brain …
in age of onset, prevalence and symptomatology. Gender dimorphisms in human-brain …
Relationship between sex biases in gene expression and sex biases in autism and Alzheimer's disease
Background Sex differences in the brain may play an important role in sex-differential
prevalence of neuropsychiatric conditions. Methods In order to understand the …
prevalence of neuropsychiatric conditions. Methods In order to understand the …
Sex differences in the human brain transcriptome of cases with schizophrenia
Background While schizophrenia differs between males and females in the age of onset,
symptomatology, and disease course, the molecular mechanisms underlying these …
symptomatology, and disease course, the molecular mechanisms underlying these …
Large-scale transcriptomics studies provide insight into sex differences in depression
Major depressive disorder (MDD) is a leading cause of disability, affecting more than 300
million people worldwide. We first review the well-known sex difference in incidence of …
million people worldwide. We first review the well-known sex difference in incidence of …
Sex-stratified single-cell RNA-Seq analysis identifies sex-specific and cell type-specific transcriptional responses in Alzheimer's disease across two brain regions
SA Belonwu, Y Li, D Bunis, AA Rao, CW Solsberg… - Molecular …, 2022 - Springer
Alzheimer's disease (AD) is a pervasive neurodegenerative disorder that disproportionately
affects women. Since neural anatomy and disease pathophysiology differ by sex …
affects women. Since neural anatomy and disease pathophysiology differ by sex …
Gender-specific gene expression in post-mortem human brain: localization to sex chromosomes
Gender differences in brain development and in the prevalence of neuropsychiatric
disorders such as depression have been reported. Gender differences in human brain might …
disorders such as depression have been reported. Gender differences in human brain might …
Post-mortem molecular profiling of three psychiatric disorders
Background Psychiatric disorders are multigenic diseases with complex etiology that
contribute significantly to human morbidity and mortality. Although clinically distinct, several …
contribute significantly to human morbidity and mortality. Although clinically distinct, several …
Sex-specific differences in the transcriptome of the human dorsolateral prefrontal cortex in schizophrenia
Schizophrenia presents clinical and biological differences between males and females. This
study investigated transcriptional profiles in the dorsolateral prefrontal cortex (DLPFC) using …
study investigated transcriptional profiles in the dorsolateral prefrontal cortex (DLPFC) using …