Chromosome segregation in female germ cells and early embryonic blastomeres is known
to be highly prone to errors. The resulting aneuploidy is therefore the most frequent cause of …

Chromosome segregation in female germ cells and early embryonic blastomeres is known
to be highly prone to errors. The resulting aneuploidy is therefore the most frequent reason …

Abnormal chromosome number, or aneuploidy, is common in early mammalian embryos,
although the underlying cell biological basis is still incompletely understood. New research …

Early embryogenesis is marked by a frail Spindle Assembly Checkpoint (SAC). The time of
SAC acquisition varies depending on the species, cell size or a yet to be uncovered …

Control mechanisms of spindle assembly and chromosome segregation are vital for
preventing aneuploidy during cell division. The mammalian germ cells and embryos are …

Chromosome segregation errors during mammalian preimplantation development cause"
mosaic" embryos comprising a mixture of euploid and aneuploid cells, which reduce the …

The spindle assembly checkpoint (SAC) is a surveillance mechanism that monitors the
quality of the spindle during division and blocks anaphase entry in the presence of …

The generation of a viable, diploid organism depends on the formation of haploid gametes,
oocytes, and spermatocytes, with the correct number of chromosomes. Halving the genome …

The spindle assembly checkpoint (SAC) maintains the fidelity of chromosome segregation
during mitosis. Nonpathogenic cells lacking the SAC are typically only found in cleavage …

Errors in chromosome segregation or distribution may result in aneuploid embryo formation,
which causes implantation failure, spontaneous abortion, genetic diseases, or embryo …