Alternative splicing (AS) contributes to the biological heterogeneity between species, sexes,
tissues, and cell types. Many diseases are either caused by alterations in AS or by …

Alternative splicing is a post-transcriptional regulatory mechanism producing multiple
distinct mRNA molecules from a single pre-mRNA. Alternative splicing has a prominent role …

Identification of cis-directed splicing events is instrumental in elucidating the genetic basis of
splicing changes. In this study, we introduce isoLASER, a computational method leveraging …

Motivation: Gene expression and alternative splicing are strictly regulated processes that
shape brain development and determine the cellular identity of differentiated neural cell …

Although alternative splicing is a fundamental and pervasive aspect of gene expression in
higher eukaryotes, it is often omitted from single-cell studies due to quantification challenges …

Alternative splicing (AS) dramatically expands the complexity of the mammalian brain
transcriptome, but its atlas remains incomplete. Here we performed deep mRNA sequencing …

Alternative splicing (AS) occurs in more than 90% of human genes. The expression pattern
of an alternatively spliced exon is often regulated in a cell type-specific fashion. AS …

The ubiquity of RNA-seq has led to many methods that use RNA-seq data to analyze
variations in RNA splicing. However, available methods are not well suited for handling …

Alternative splicing (AS) can critically affect gene function and disease, yet mapping splicing
variations remains a challenge. Here, we propose a new approach to define and quantify …

Alternative splicing is widely acknowledged to be a crucial regulator of gene expression and
is a key contributor to both normal developmental processes and disease states. While cost …