People with autism spectrum disorder and other neurodevelopmental disorders (NDDs) are
behaviorally and medically heterogeneous. The combination of polygenicity and gene …

The human MET gene imparts a replicated risk for autism spectrum disorder (ASD), and is
implicated in the structural and functional integrity of brain. MET encodes a receptor tyrosine …

Met receptor tyrosine kinase signaling regulates the growth and development of axons and
may contribute to the wiring of cortical and limbic circuits in the rodent forebrain. Whether the …

The validity for assigning disorder risk to an autism spectrum disorder (ASD) candidate gene
comes from convergent genetic, clinical, and developmental neurobiology data. Here, we …

The key developmental milestone events of the human brain, such as neurogenesis,
synapse formation, maturation, and plasticity, are determined by a myriad of molecular …

The establishment of appropriate neural circuitry depends on the coordination of multiple
developmental events across space and time. These events include proliferation, migration …

Background Our laboratory discovered that the gene encoding the receptor tyrosine kinase,
MET, contributes to autism risk. Expression of MET is reduced in human postmortem …

In this chapter, we will briefly discuss recent literature on the role of MET receptor tyrosine
kinase (RTK) in brain development and how perturbation of MET signaling may alter normal …

Signaling via MET receptor tyrosine kinase (MET) has been implicated in a number of
neurodevelopmental events, including cell migration, dendritic and axonal development and …

As genes that confer increased risk for autism spectrum disorder (ASD) are identified, a
crucial next step is to determine how these risk factors impact brain structure and function …