Hypoxia-induced drug resistance (HDR) is a critical issue in cancer therapy. The presence
of hypoxic tumor cells impedes drug uptake and reduces the cytotoxicity of …

As a non-invasive therapeutic, radiotherapy (RT) has been extensively used for solid tumor
treatment. However, intratumoral hypoxia leads to severe RT resistance or failure. Moreover …

Background Hypoperfusion or resultant hypoxia in solid tumours is a main reason for
therapeutic resistance. Augmenting the blood perfusion of hypovascular tumours might …

Tumor hypoperfusion not only impedes therapeutic drug delivery and accumulation, but also
leads to a hypoxic and acidic tumor microenvironment, resulting in tumor proliferation …

The low sensitivity of hypoxic regions in solid tumors to radiotherapy and chemotherapy
remains a major obstacle to cancer treatment. By taking advantage of hypoxic-activated …

Tumor microenvironment influences the efficacy of anti-cancer therapies. The dysfunctional
tumor vasculature limits the efficiency of oxygenation and drug delivery to reduce treatment …

Background The hypoxic microenvironment promotes tumor resistance to most treatments,
especially highly oxygen-dependent sonodynamic therapy (SDT). Method and Results In …

Background Hypoxia-activated prodrug (HAP) is a promising candidate for highly tumor-
specific chemotherapy. However, the oxygenation heterogeneity and dense extracellular …

Suspensions of oxygen‐filled bubbles are under active investigation as potential means of
relieving tissue hypoxia. Intravenous administration of large quantities of bubbles is …

Chemotherapy has become a critical treatment for many cancer types. However, its efficacy
is hindered by chemoresistance and limited drug accumulation induced by the hypoxic …