Molecular states during acute COVID-19 reveal distinct etiologies of long-term sequelae

RC Thompson, NW Simons, L Wilkins, E Cheng… - Nature Medicine, 2023 - nature.com
Post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
infection are debilitating, clinically heterogeneous and of unknown molecular etiology. A …

Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

F Liew, C Efstathiou, S Fontanella, M Richardson… - Nature …, 2024 - nature.com
One in ten severe acute respiratory syndrome coronavirus 2 infections result in prolonged
symptoms termed long coronavirus disease (COVID), yet disease phenotypes and …

Distinct systemic and mucosal immune responses during acute SARS-CoV-2 infection

N Smith, P Goncalves, B Charbit, L Grzelak… - Nature …, 2021 - nature.com
Coordinated local mucosal and systemic immune responses following severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection either protect against …

SARS-CoV-2 reservoir in post-acute sequelae of COVID-19 (PASC)

AD Proal, MB VanElzakker, S Aleman, K Bach… - Nature …, 2023 - nature.com
Millions of people are suffering from Long COVID or post-acute sequelae of COVID-19
(PASC). Several biological factors have emerged as potential drivers of PASC pathology …

Data-driven identification of post-acute SARS-CoV-2 infection subphenotypes

H Zhang, C Zang, Z Xu, Y Zhang, J Xu, J Bian… - Nature Medicine, 2023 - nature.com
The post-acute sequelae of SARS-CoV-2 infection (PASC) refers to a broad spectrum of
symptoms and signs that are persistent, exacerbated or newly incident in the period after …

[HTML][HTML] Post-acute COVID-19 syndrome

A Nalbandian, K Sehgal, A Gupta, MV Madhavan… - Nature medicine, 2021 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogen
responsible for the coronavirus disease 2019 (COVID-19) pandemic, which has resulted in …

[HTML][HTML] Longitudinal analyses reveal immunological misfiring in severe COVID-19

C Lucas, P Wong, J Klein, TBR Castro, J Silva… - Nature, 2020 - nature.com
Recent studies have provided insights into the pathogenesis of coronavirus disease 2019
(COVID-19),,–. However, the longitudinal immunological correlates of disease outcome …

Global absence and targeting of protective immune states in severe COVID-19

AJ Combes, T Courau, NF Kuhn, KH Hu, A Ray… - Nature, 2021 - nature.com
Although infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
pleiotropic and systemic effects in some individuals,–, many others experience milder …

Heterogenous humoral and cellular immune responses with distinct trajectories post-SARS-CoV-2 infection in a population-based cohort

D Menges, KD Zens, T Ballouz, N Caduff… - Nature …, 2022 - nature.com
To better understand the development of SARS-CoV-2-specific immunity over time, a
detailed evaluation of humoral and cellular responses is required. Here, we characterize …

Delayed production of neutralizing antibodies correlates with fatal COVID-19

C Lucas, J Klein, ME Sundaram, F Liu, P Wong… - Nature medicine, 2021 - nature.com
Recent studies have provided insights into innate and adaptive immune dynamics in
coronavirus disease 2019 (COVID-19). However, the exact features of antibody responses …