Multienzyme‐Like Nanozyme Encapsulated Ocular Microneedles for Keratitis Treatment

S Liu, Q Bai, Y Jiang, Y Gao, Z Chen, L Shang… - Small, 2024 - Wiley Online Library
Keratitis, an inflammation of the cornea caused by bacterial or fungal infections, is one of the
leading causes of severe visual disability and blindness. Keratitis treatment requires both …

Construction of graphene quantum dot-based dissolving microneedle patches for the treatment of bacterial keratitis

Y Fang, L Zhuo, H Yuan, H Zhao, L Zhang - International Journal of …, 2023 - Elsevier
Bacterial keratitis (BK) is an ophthalmic infection caused by bacteria and poses a risk of
blindness. Numerous drugs have been used to treat BK, the majority suffered from limited …

Self‐Implantable Core–Shell Microneedle Patch for Long‐Acting Treatment of Keratitis via Programmed Drug Release

X Jiang, Y Jin, Y Zeng, P Shi, W Li - Small, 2024 - Wiley Online Library
Bacteria‐induced keratitis is a major cause of corneal blindness in both developed and
developing countries. Instillation of antibiotic eyedrops is the most common management of …

Tannin coordinated nanozyme composite-based hybrid hydrogel eye drops for prophylactic treatment of multidrug-resistant Pseudomonas aeruginosa keratitis

H Wang, F Song, J Feng, X Qi, L Ma, L Xie… - Journal of …, 2022 - Springer
Pseudomonas aeruginosa infection is a severe acute suppurative ulcer that engulfs virtually
the entire tissue in a short period and leads to devastating destruction. Antibiotic therapy is a …

Development of nanodrug-based eye drops with good penetration properties and ROS responsiveness for controllable release to treat fungal keratitis

P Niu, Y Wu, F Zeng, S Zhang, S Liu, H Gao - NPG Asia Materials, 2023 - nature.com
Fungal keratitis is challenging to diagnose and treat and remains a significant cause of
blindness worldwide. The easiest and most common method of drug delivery for patients …

Frozen reinforced microneedles loaded with NIR-photothermal nanozyme for keratitis treatment

B Kong, R Liu, J Shan, M Li, X Zhou, Y Zhao - Nano Today, 2023 - Elsevier
Developing a potential alternative with safe, minimally invasive, and highly effective
antimicrobial properties is significant for treating bacterial keratitis. In this paper, we present …

DNA Nanoflower Eye Drops with Antibiotic‐Resistant Gene Regulation Ability for MRSA Keratitis Target Treatment

M Ran, R Sun, J Yan, AT Pulliainen, Y Zhang, H Zhang - Small, 2023 - Wiley Online Library
Methicillin‐resistant Staphylococcus aureus (MRSA) biofilm‐associated bacterial keratitis is
highly intractable, with strong resistance to β‐lactam antibiotics. Inhibiting the MRSA …

Fabrication of nanozyme-thixotropic anionic hydrogel coating with multi-enzyme-mimicking activity for the treatment of fungal keratitis

D Shi, X Qi, L Ma, L Zhao, S Dou, Y Wang… - Chemical Engineering …, 2024 - Elsevier
Fungal keratitis is the primary cause of infectious corneal blindness in China. Currently,
early-stage treatment mainly involves the frequent administration of antifungal medications …

Dissolvable hybrid microneedle patch for efficient delivery of curcumin to reduce intraocular inflammation

H Shi, S Huai, H Wei, Y Xu, L Lei, H Chen, X Li… - International Journal of …, 2023 - Elsevier
Intraocular inflammation seriously impairs vision, and the effectiveness of intraocular drug
delivery is hampered by various physiological barriers, such as the corneal barrier. In this …

Hydroxypropyl methacrylamide-based copolymeric nanoparticles loaded with moxifloxacin as a mucoadhesive, cornea-penetrating nanomedicine eye drop with …

S Ch, P Mishra, H Bhatt, B Ghosh, S Roy… - Colloids and Surfaces B …, 2021 - Elsevier
Bacterial keratitis (BK) is a leading cause of visual impairment. The fluoroquinolone
antibiotic moxifloxacin (Mox), being highly water-soluble, suffers from poor corneal …