Importance Schizophrenia is a common, severe mental illness that most clinicians will
encounter regularly during their practice. This report provides an overview of the clinical …

All current drugs approved to treat schizophrenia appear to exert their antipsychotic effects
through blocking the dopamine D2 receptor. Recent meta-analyses and comparative …

Schizophrenia is a common and debilitating illness, characterized by chronic psychotic
symptoms and psychosocial impairment that exact considerable human and economic …

The neurodevelopmental hypothesis of schizophrenia posits an interaction between multiple
susceptibility genes and one or more environmental insults in early life, resulting in altered …

Schizophrenia is commonly considered a neurodevelopmental disorder that is associated
with significant morbidity; however, unlike other neurodevelopmental disorders, the …

Schizophrenia is a highly disabling disorder whose causes remain to be better understood,
and treatments have to be improved. However, several recent advances have been made in …

New findings are rapidly revealing an increasingly detailed image of neural-and molecular-
level dysfunction in schizophrenia, distributed throughout interconnected cortico–striato …

Schizophrenia is one of the most complex and disabling diseases to affect mankind.
Relatively little is known about its nature and its origins, and available treatments are …

Despite 50+ years of drug discovery, current antipsychotics have limited efficacy against
negative and cognitive symptoms of schizophrenia, and are ineffective—with the exception …

Schizophrenia appears to bea neurodevelopmental disorder involving dysfunction prefrontal
and temporal cortical neural systems. Recent data implicate presynaptic changes in …