Proteins circulating in the blood are critical for age-related disease processes; however, the
serum proteome has remained largely unexplored. To this end, 4137 proteins covering most …

The increasing prevalence of type 2 diabetes poses a major challenge to societies
worldwide. Blood-based factors like serum proteins are in contact with every organ in the …

Aging is a predominant risk factor for several chronic diseases that limit healthspan.
Mechanisms of aging are thus increasingly recognized as potential therapeutic targets …

Circulating proteins can be used to diagnose and predict disease-related outcomes. A deep
serum proteome survey recently revealed close associations between serum protein …

With the growing number of genetic association studies, the genotype-phenotype atlas has
become increasingly more complex, yet the functional consequences of most disease …

Proteins are effector molecules that mediate the functions of genes, and modulate
comorbidities,,,,,,–, behaviors and drug treatments. They represent an enormous potential …

Older age is a strong shared risk factor for many chronic diseases, and there is increasing
interest in identifying aging biomarkers. Here, a proteomic analysis of 1301 plasma proteins …

Proteomic analysis of cells, tissues and body fluids has generated valuable insights into the
complex processes influencing human biology. Proteins represent intermediate phenotypes …

Blood circulating proteins are confounded readouts of the biological processes that occur in
different tissues and organs. Many proteins have been linked to complex disorders and are …

Circulating proteins are vital in human health and disease and are frequently used as
biomarkers for clinical decision-making or as targets for pharmacological intervention. Here …