Glutathione homeostasis and functions: potential targets for medical interventions

VI Lushchak - Journal of amino acids, 2012 - Wiley Online Library
Glutathione (GSH) is a tripeptide, which has many biological roles including protection
against reactive oxygen and nitrogen species. The primary goal of this paper is to …

[图书][B] Glutathione: metabolism and physiological functions

J Vina - 1990 - api.taylorfrancis.com
In the last two decades our knowledge of the functions of glutathione in cell metabolism has
been constantly increasing. Bibliometric studies show a growing interest in glutathione by …

The importance of glutathione in human disease

DM Townsend, KD Tew, H Tapiero - Biomedicine & pharmacotherapy, 2003 - Elsevier
Reduced glutathione (GSH) is the most prevalent non-protein thiol in animal cells. Its de
novo and salvage synthesis serves to maintain a reduced cellular environment and the …

Glutathione in health and disease: pharmacotherapeutic issues

BM Lomaestro, M Malone - Annals of Pharmacotherapy, 1995 - journals.sagepub.com
Objective: To review the current research and importance of glutathione (GSH) therapy in
health and disease and to provide a basic overview of the widespread use and interest in …

The changing faces of glutathione, a cellular protagonist

A Pompella, A Visvikis, A Paolicchi, V De Tata… - Biochemical …, 2003 - Elsevier
Glutathione (GSH) has been described for a long time just as a defensive reagent against
the action of toxic xenobiotics (drugs, pollutants, carcinogens). As a prototype antioxidant, it …

Regulation of glutathione synthesis

SC Lu - Molecular aspects of medicine, 2009 - Elsevier
Glutathione (GSH) is a ubiquitous intracellular peptide with diverse functions that include
detoxification, antioxidant defense, maintenance of thiol status, and modulation of cell …

Glutathione: overview of its protective roles, measurement, and biosynthesis

HJ Forman, H Zhang, A Rinna - Molecular aspects of medicine, 2009 - Elsevier
This review is the introduction to a special issue concerning, glutathione (GSH), the most
abundant low molecular weight thiol compound synthesized in cells. GSH plays critical roles …

Glutathione catabolism as a signaling mechanism

A Paolicchi, S Dominici, L Pieri, E Maellaro… - Biochemical …, 2002 - Elsevier
Glutathione (GSH) is the main intracellular thiol antioxidant, and as such participates in a
number of cellular antitoxic and defensive functions. Nevertheless, non-antioxidant functions …

Glutathione: an overview of biosynthesis and modulation

ME Anderson - Chemico-biological interactions, 1998 - Elsevier
Glutathione (GSH; γ-glutamylcysteinylglycine) is ubiquitous in mammalian and other living
cells. It has several important functions, including protection against oxidative stress. It is …

Metabolism and antioxidant function of glutathione

D Gerard-Monnier, J Chaudiere - Pathologie-biologie, 1996 - europepmc.org
Glutathione (gamma-glutamyl-cysteinyl-glycine or GSH) is a cysteine-containing tripeptide
with reducing and nucleophilic properties which play an important role in cellular protection …