Calcimimetic agents allosterically increase the calcium ion sensitivity of the calcium-sensing
receptor (CaSR), which is expressed in the tubular system and to a lesser extent in …

Besides its primary function in maintaining systemic calcium homeostasis, the calcium-
sensing receptor (CaSR) is expressed by many cell types, with different, sometimes …

Calcimimetics allosterically increase the calcium ion sensitivity of the calcium-sensing
receptor (CaSR). Using a CaSR knockdown in podocytes and a podocyte-specific CaSR …

Background/Aims: Recent studies provided compelling evidence that stimulation of the
calcium sensing receptor (CaSR) exerts direct renoprotective action at the glomerular …

Chronic alterations in calcium (Ca2+) signalling in podocytes have been shown to cause
proteinuria and progressive glomerular diseases. However, it is unclear whether short Ca2+ …

Calcium-sensing receptor (CaSR) has been demonstrated to be present in several tissues
and cells unrelated to systemic calcium homeostasis, where it regulates a series of diverse …

The ability to monitor changes in the ionic composition of the extracellular environment is a
crucial feature that has evolved in all living organisms. The cloning and characterization of …

Podocyte injury induced by hyperglycemia is the main cause of kidney dysfunction in
diabetic nephropathy. However, the underlying mechanism is unclear. Store-operated Ca 2+ …

Studies over the last decade have markedly broadened our understanding of store-operated
Ca2+ channels (SOCs) and their roles in kidney diseases and podocyte dysfunction …

Background Impaired mineral ion metabolism is a hallmark of CKD–metabolic bone
disorder. It can lead to pathologic vascular calcification and is associated with an increased …