Osteosarcoma is one of the most common primary tumours of the bone, with a 5‐year
survival rate of less than 20% after the development of metastases. Osteosarcoma is highly …

Over the past decade, researchers have highlighted the importance of mechanical cues of
the metastatic niche such as matrix stiffness, topography, mechanical stresses, and …

Evidence from physical sciences in oncology increasingly suggests that the interplay
between the biophysical tumor microenvironment and genetic regulation has significant …

Dynamic and heterogeneous interaction between tumor cells and the surrounding
microenvironment fuels the occurrence, progression, invasion, and metastasis of solid …

Pathological remodeling of the extracellular matrix (ECM) by activated myofibroblasts is a
hallmark of fibrotic diseases and desmoplastic tumors. Activation of myofibroblasts occurs in …

Cross-talk between tumor cells and mechanical stress in the tumor microenvironment has
been shown to be involved in carcinogenesis. High mechanical stress in tumors can alter …

Cross-talk between tumor cells and their microenvironment is critical for malignant
progression. Cross-talk mediators, including soluble factors and direct cell contact, have …

Metastasis is a complicated, multistep process that is responsible for over 90% of cancer-
related death. Metastatic disease or the movement of cancer cells from one site to another …

Osteosarcomas are the most frequent primary bone sarcomas, affecting mainly children,
adolescents, and young adults, and with a second peak of incidence in elderly individuals …

Mechanobiology is a rapidly growing research area focused on how mechanical forces and
properties influence biological systems at the cell, molecular, and tissue level, and how …