Challenges and recent progress in drug discovery for tropical diseases

M De Rycker, B Baragaña, SL Duce, IH Gilbert - Nature, 2018 - nature.com
Infectious tropical diseases have a huge effect in terms of mortality and morbidity, and
impose a heavy economic burden on affected countries. These diseases predominantly …

Innovation in neglected tropical disease drug discovery and development

HB Weng, HX Chen, MW Wang - Infectious diseases of poverty, 2018 - mednexus.org
Background: Neglected tropical diseases (NTDs) are closely related to poverty and affect
over a billion people in developing countries. The unmet treatment needs cause high …

Drugs for neglected diseases: a failure of the market and a public health failure?

P Trouiller, E Torreele, P Olliaro, N White… - Tropical Medicine & …, 2001 - Wiley Online Library
Infectious diseases cause the suffering of hundreds of millions of people, especially in
tropical and subtropical areas. Effective, affordable and easy‐to‐use medicines to fight these …

Finding cures for tropical diseases: is open source an answer?

SM Maurer, A Rai, A Sali - PLoS medicine, 2004 - journals.plos.org
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The role of natural products in drug discovery and development against neglected tropical diseases

PM Cheuka, G Mayoka, P Mutai, K Chibale - Molecules, 2016 - mdpi.com
Endemic in 149 tropical and subtropical countries, neglected tropical diseases (NTDs) affect
more than 1 billion people annually, including 875 million children in developing …

The pipeline for drugs for control and elimination of neglected tropical diseases: 2. Oral anti-infective drugs and drug combinations for off-label use

KM Pfarr, AK Krome, I Al-Obaidi, H Batchelor… - Parasites & …, 2023 - Springer
In its 'Road map for neglected tropical diseases 2021–2030', the World Health Organization
outlined its targets for control and elimination of neglected tropical diseases (NTDs) and …

Drug discovery and development for neglected parasitic diseases

AR Renslo, JH McKerrow - Nature chemical biology, 2006 - nature.com
Diseases caused by tropical parasites affect hundreds of millions of people worldwide but
have been largely neglected for drug development because they affect poor people in poor …

Advancing drug innovation for neglected diseases—criteria for lead progression

S Nwaka, B Ramirez, R Brun, L Maes… - PLoS neglected …, 2009 - journals.plos.org
The current drug R&D pipeline for most neglected diseases remains weak, and unlikely to
support registration of novel drug classes that meet desired target product profiles in the …

Recent approaches to chemical discovery and development against malaria and the neglected tropical diseases human African trypanosomiasis and schistosomiasis

M Njoroge, NM Njuguna, P Mutai… - Chemical …, 2014 - ACS Publications
Neglected tropical diseases (NTDs) refer to a group of infectious diseases, which though
treatable and/or preventable, remain a leading cause of morbidity and mortality among the …

Drug development for neglected diseases: a deficient market and a public-health policy failure

P Trouiller, P Olliaro, E Torreele, J Orbinski, R Laing… - The Lancet, 2002 - thelancet.com
There is a lack of effective, safe, and affordable pharmaceuticals to control infectious
diseases that cause high mortality and morbidity among poor people in the developing …