3D cell culture can mimic tumor pathophysiology, which reflects cellular morphology and
heterogeneity, strongly influencing gene expression, cell behavior, and intracellular …

Research on the 3D culturing of cancer cells that better mimic in vivo solid tumors is
important for efficient drug screening. Herein, a new platform that effectively facilitates the …

Pancreatic cancer, notorious for its grim 10% five-year survival rate, poses significant clinical
challenges, largely due to late-stage diagnosis and limited therapeutic options. This review …

Even though in vitro co-culture tumor spheroid model plays an important role in screening
drug candidates, its wide applications are currently limited due to the lack of reliable and …

Advanced-stage gynecologic cancer remains a life-threatening disease. Here, we present a
protocol for establishment of stable in vitro 3D spheroid cells derived from human uterine …

Background Ovarian cancer is a highly aggressive malignant disease in gynecologic
cancer. It is an urgent task to develop three-dimensional (3D) cell models in vitro and dissect …

Ovarian cancer, one of the most dreadful malignancies of the female reproductive system,
poses a lethal threat to women worldwide. In this dissertation, the objective was to introduce …

Three-dimensional (3D) tumor spheroids offer unprecedented capability for drug screening
because of their unique features such as spatial 3D structure, relevant physiological …

Advanced stage ovarian cancer is challenging to treat due to widespread seeding of tumor
spheroids throughout the mesothelial lining of the peritoneal cavity. In this work, a …

Graphene oxide (GO) is one of the most popular nanomaterials that widely used to achieve
effective cancer treatment. In this study, a novel, folic acid-decorated graphene oxide (FA …