Medulloblastoma, a malignant brain tumour primarily diagnosed during childhood, has
recently been the focus of intensive molecular profiling efforts, profoundly advancing our …

Background: Medulloblastoma is the most common malignant brain tumor in children,
currently treated uniformly based on histopathology and clinico-radiological risk stratification …

The division of medulloblastoma into different subgroups by microarray expression profiling
has dramatically changed our perspective of this malignant childhood brain tumour. Now …

Recent efforts at stratifying medulloblastomas based on their molecular features have
revolutionized our understanding of this morbidity. Collective efforts by multiple independent …

Critical discoveries over the past two decades have transformed our understanding of
medulloblastoma from a single entity into a clinically and biologically heterogeneous …

Brain tumors are the leading cause of cancer-related death in children, and
medulloblastoma (MB) is the most common malignant pediatric brain tumor. Advances in …

Medulloblastoma is the most common pediatric malignant brain tumor. Advances in
molecular profiling have uncovered significant heterogeneity among medulloblastomas and …

In 2012, an international consensus paper reported that medulloblastoma comprises four
molecular subgroups (WNT, SHH, Group 3, and Group 4), each associated with distinct …

As advances in the molecular and genetic profiling of pediatric medulloblastoma evolve,
associations with prognosis and treatment are found (prognostic and predictive biomarkers) …

There is a pressing need to identify therapeutic targets in tumors with low mutation rates
such as the malignant pediatric brain tumor medulloblastoma. To address this challenge, we …