This is the second of two invited articles reviewing the development of nucleoside analogue
antiviral drugs, written for a target audience of virologists and other non-chemists, as well as …

This is the first of two invited articles reviewing the development of nucleoside-analogue
antiviral drugs, written for a target audience of virologists and other non-chemists, as well as …

This article provides an overview of the field of nucleoside antiviral agents in so far as they
have some level of current interest. It considers compounds in a number of structural …

Nucleosides exhibit a broad spectrum of biological activity that generally results from their
ability to inhibit specific enzymes. This activity has led to their use in the development of …

Conspectus Modified nucleosides show therapeutic promise for antiviral therapies.
However, issues including the emergence of drug resistance, toxicity, and coinfections have …

Nucleosides are the building blocks required in constructing nucleic acids. As we learned in
school, billions of combinations are possible using only four different nucleosides, and thus …

Nucleoside analogues have been in clinical use for almost 50 years and have become
cornerstones of treatment for patients with cancer or viral infections. The approval of several …

The emergence or re-emergence of viruses with epidemic and/or pandemic potential, such
as Ebola, Zika, Middle East Respiratory Syndrome (MERS-CoV), Severe Acute Respiratory …

A variety of nucleoside analogues have now been discovered which expand the antiviral
and anticancer spectrum and/or modify the pharmacological and/or pharmacokinetic …

Depending on the target enzyme with which they interact, nucleoside analogues exhibit
marked differences in their antiviral activity spectrum. The activity spectrum of those …