Overcoming immune evasion in melanoma

K Eddy, S Chen - International journal of molecular sciences, 2020 - mdpi.com
Melanoma is the most aggressive and dangerous form of skin cancer that develops from
transformed melanocytes. It is crucial to identify melanoma at its early stages, in situ, as it is …

[HTML][HTML] Immune system and melanoma biology: a balance between immunosurveillance and immune escape

A Passarelli, F Mannavola, LS Stucci, M Tucci… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Melanoma is one of the most immunogenic tumors and its relationship with host immune
system is currently under investigation. Many immunomodulatory mechanisms, favoring …

Unraveling the crosstalk between melanoma and immune cells in the tumor microenvironment

M Marzagalli, ND Ebelt, ER Manuel - Seminars in cancer biology, 2019 - Elsevier
Cutaneous melanoma is the most common skin cancer with an incidence that has been
rapidly increasing in the past decades. Melanomas are among the most immunogenic …

Signal pathways of melanoma and targeted therapy

W Guo, H Wang, C Li - Signal transduction and targeted therapy, 2021 - nature.com
Melanoma is the most lethal skin cancer that originates from the malignant transformation of
melanocytes. Although melanoma has long been regarded as a cancerous malignancy with …

[HTML][HTML] Pathways and therapeutic targets in melanoma

E Shtivelman, MA Davies, P Hwu, J Yang, M Lotem… - Oncotarget, 2014 - ncbi.nlm.nih.gov
This review aims to summarize the current knowledge of molecular pathways and their
clinical relevance in melanoma. Metastatic melanoma was a grim diagnosis, but in recent …

Mechanisms of immune activation and regulation: lessons from melanoma

S Kalaora, A Nagler, JA Wargo, Y Samuels - Nature Reviews Cancer, 2022 - nature.com
Melanoma, a skin cancer that develops from pigment cells, has been studied intensively,
particularly in terms of the immune response to tumours, and has been used as a model for …

Immune system evasion as hallmark of melanoma progression: the role of dendritic cells

M Tucci, A Passarelli, F Mannavola, C Felici… - Frontiers in …, 2019 - frontiersin.org
Melanoma is an immunogenic tumor whose relationship with immune cells resident in the
microenvironment significantly influences cancer cell proliferation, progression, and …

Decoding melanoma development and progression: identification of therapeutic vulnerabilities

K Eddy, R Shah, S Chen - Frontiers in oncology, 2021 - frontiersin.org
Melanoma, a cancer of the skin, arises from transformed melanocytes. Melanoma has the
highest mutational burden of any cancer partially attributed to UV induced DNA damage …

Melanoma: from melanocyte to genetic alterations and clinical options

C Bertolotto - Scientifica, 2013 - Wiley Online Library
Metastatic melanoma remained for decades without any effective treatment and was thus
considered as a paradigm of cancer resistance. Recent progress with understanding of the …

The melanoma revolution: from UV carcinogenesis to a new era in therapeutics

JA Lo, DE Fisher - Science, 2014 - science.org
Melanoma, the deadliest form of skin cancer, is an aggressive disease that is rising in
incidence. Although melanoma is a historically treatment-resistant malignancy, in recent …